Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Qi Li; Anran Huo; Mengqi Li; Jiali Wang; Qiao Yin; Lumiao Chen; Xin Chu; Yuan Qin; Yuwan Qi; Yang Li; Hengxiang Cui; Qifei Cong

doi:10.1016/j.gendis.2023.02.016

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Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Review article | 更新时间：2024-02-04

- Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases
- Genes & Diseases Vol. 1, Issue 1, Pages: 294-305(2024)
- 作者机构：
  
  1. Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University,Jiangsu,Suzhou,China,215123
  2. Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China,215004
  3. Department of Nephrology, The Second Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China,215004
  4. Department of Emergency Center, The Second Affiliated Hospital of Nantong University,Jiangsu,Nantong,China,226001
  5. Department of Neurology, Huzhou Central Hospital, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine,Zhejiang,Huzhou,China,313000
  6. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences,Shanghai,China,200031
  7. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine,Shanghai,China,200030
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.016
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Qi Li, Anran Huo, Mengqi Li, et al. Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases. [J]. Genes & Diseases 1(1):294-305(2024)
DOI：

Qi Li, Anran Huo, Mengqi Li, et al. Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases. [J]. Genes & Diseases 1(1):294-305(2024) DOI： 10.1016/j.gendis.2023.02.016.

摘要

Abstract

dhesion G protein-coupled receptors (aGPCRs) are the second largest diverse group within the GPCR superfamily

which play critical roles in many physiological and pathological processes through cell–cell and cell–extracellular matrix interactions. The adhesion GPCR Adgrg6

also known as GPR126

is one of the better-characterized aGPCRs. GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals. Current studies have extended our understanding of GPR126-mediated roles during development and in human diseases. In this review

we highlighted these recent advances in GPR126 in expression profile

molecular structure

ligand–receptor interactions

and associated physiological and pathological functions in development and diseases.

关键词

Keywords

Adhesion G protein-coupled receptorFunctionGPR126/Adgrg6LigandStructure

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