The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities
- Genes & Diseases Vol. 1, Issue 1, Pages: 252-267(2024)
- 作者机构：
1. The First Clinical Medical College, Shandong University of Traditional Chinese Medicine,Shandong,Jinan,China,250013
2. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine,Shandong,Jinan,China,250013
3. Department of Gastroenterology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200233
- 作者简介：
- 基金信息：
DOI：10.1016/j.gendis.2023.02.013
CLC：Published：2024，
Published Online：1 January 2024，
扫 描 看 全 文
Yunan Shan, Wei Chen, Yanbin Li. The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities. [J]. Genes & Diseases 1(1):252-267(2024)
Yunan Shan, Wei Chen, Yanbin Li. The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities. [J]. Genes & Diseases 1(1):252-267(2024) DOI： 10.1016/j.gendis.2023.02.013.
摘要
Abstract
N6-methyladenosine (m
6
A) modifications
as one of the most common forms of internal RNA chemical modifications in eukaryotic cells
have gained increasing attention in recent years. The m
6
A RNA modifications exert various crucial roles in various biological processes
such as embryonic development
neurogenesis
circadian rhythms
and tumorigenesis. Recent advances have highlighted that m
6
A RNA modification plays an important role in immune response
especially in the initiation and progression of autoimmune diseases. In this review
we summarized the regulatory mechanisms of m
6
A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the potential role of m
6
A RNA methylation in the pathogenesis of autoimmune diseases
thus providing possible biomarkers and potential targets for the prevention and treatment of autoimmune diseases.
关键词
Keywords
Adaptive immunityAutoimmune diseasesInnate immunityImmune responsem6A RNA methylation
references
1 I.A. Roundtree, C. HeRNA epigenetics: chemical messages for posttranscriptional gene regulation Curr Opin Chem Biol, 30 (2016), pp. 46-51
2 P. Boccaletto, F. Stefaniak, A. Ray, et al.MODOMICS: a database of RNA modification pathways. 2021 update Nucleic Acids Res, 50 (D1) (2022), pp. D231-D235
3 H. Zhong, H.F. Tang, Y. KaiN6-methyladenine RNA modification (m6A): an emerging regulator of metabolic diseases Curr Drug Targets, 21 (11) (2020), pp. 1056-1067
4 H. Shi, J. Wei, C. HeWhere, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers Mol Cell, 74 (4) (2019), pp. 640-650
5 P.F. AgrisBringing order to translation: the contributions of transfer RNA anticodon-domain modifications EMBO Rep, 9 (7) (2008), pp. 629-635
6 R.P. Perry, D.E. KelleyExistence of methylated messenger RNA in mouse L cells Cell, 1 (1974), pp. 37-42
7 R. Desrosiers, K. Friderici, F. RottmanIdentification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells Proc Natl Acad Sci U S A, 71 (10) (1974), pp. 3971-3975
8 D. Dominissini, S. Moshitch-Moshkovitz, S. Schwartz, et al.Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq Nature, 485 (7397) (2012), pp. 201-206
9 N. van Tran, F.G.M. Ernst, B.R. Hawley, et al.The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112 Nucleic Acids Res, 47 (15) (2019), pp. 7719-7733
10 M. Frye, B.T. Harada, M. Behm, et al.RNA modifications modulate gene expression during development Science, 361 (6409) (2018), pp. 1346-1349
11 L. He, H. Li, A. Wu, et al.Functions of N6-methyladenosine and its role in cancer Mol Cancer, 18 (2019), p. 176
12 D. Dixit, B.C. Prager, R.C. Gimple, et al.The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells Cancer Discov, 11 (2) (2021), pp. 480-499
13 A.M. Shafik, F. Zhang, Z. Guo, et al.N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease Genome Biol, 22 (2021), p. 17
14 L. Hu, J. Wang, H. Huang, et al.YTHDF1 regulates pulmonary hypertension through translational control of MAGED1 Am J Respir Crit Care Med, 203 (9) (2021), pp. 1158-1172
15 Z. Zhou, J. Lv, H. Yu, et al.Mechanism of RNA modification N6-methyladenosine in human cancer Mol Cancer, 19 (2020), p. 104
16 J.A. Bokar, M.E. Shambaugh, D. Polayes, et al.Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase RNA, 3 (11) (1997), pp. 1233-1247
17 D.P. Patil, C.K. Chen, B.F. Pickering, et al.m6A RNA methylation promotes XIST-mediated transcriptional repression Nature, 537 (7620) (2016), pp. 369-373
18 H. Huang, H. Weng, K. Zhou, et al.Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally Nature, 567 (7748) (2019), pp. 414-419
19 P. Śledź, M. JinekStructural insights into the molecular mechanism of the m6A writer complex Elife, 5 (2016), Article e18434
20 X. Wang, J. Feng, Y. Xue, et al.Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex Nature, 534 (7608) (2016), pp. 575-578
21 J. Liu, Y. Yue, D. Han, et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation Nat Chem Biol, 10 (2) (2014), pp. 93-95
22 Y. Wang, Y. Li, J.I. Toth, et al.N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells Nat Cell Biol, 16 (2) (2014), pp. 191-198
23 S. Geula, S. Moshitch-Moshkovitz, D. Dominissini, et al.Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation Science, 347 (6225) (2015), pp. 1002-1006
24 X.L. Ping, B.F. Sun, L. Wang, et al.Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase Cell Res, 24 (2) (2014), pp. 177-189
25 S. Schwartz, M.R. Mumbach, M. Jovanovic, et al.Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites Cell Rep, 8 (1) (2014), pp. 284-296
26 K.E. Pendleton, B. Chen, K. Liu, et al.The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention Cell, 169 (5) (2017), pp. 824-835 e14
27 A.S. Warda, J. Kretschmer, P. Hackert, et al.Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs EMBO Rep, 18 (11) (2017), pp. 2004-2014
28 J.A. Brown, C.G. Kinzig, S.J. DeGregorio, et al.Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA Proc Natl Acad Sci U S A, 113 (49) (2016), pp. 14013-14018
29 H. Ma, X. Wang, J. Cai, et al.N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation Nat Chem Biol, 15 (1) (2019), pp. 88-94
30 Y. Yue, J. Liu, X. Cui, et al.VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation Cell Discov, 4 (2018), p. 10
31 J. Wen, R. Lv, H. Ma, et al.Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal Mol Cell, 69 (6) (2018), pp. 1028-1038.e6
32 B. Moindrot, A. Cerase, H. Coker, et al.A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing Cell Rep, 12 (4) (2015), pp. 562-572
33 K. Růžička, M. Zhang, A. Campilho, et al.Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI New Phytol, 215 (1) (2017), pp. 157-172
34 G. Jia, Y. Fu, X. Zhao, et al.N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Nat Chem Biol, 7 (12) (2011), pp. 885-887
35 G. Zheng, J.A. Dahl, Y. Niu, et al.ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility Mol Cell, 49 (1) (2013), pp. 18-29
36 X. Zhang, L.H. Wei, Y. Wang, et al.Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates Proc Natl Acad Sci U S A, 116 (8) (2019), pp. 2919-2924
37 Y. Fu, G. Jia, X. Pang, et al.FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA Nat Commun, 4 (2013), p. 1798
38 T. Wang, S. Kong, M. Tao, et al.The potential role of RNA N6-methyladenosine in Cancer progression Mol Cancer, 19 (2020), p. 88
39 J. Wei, F. Liu, Z. Lu, et al.Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm Mol Cell, 71 (6) (2018), pp. 973-985.e5
40 J. Mauer, Jaffrey SR. Ftom6Am, and the hypothesis of reversible epitranscriptomic mRNA modifications FEBS Lett, 592 (12) (2018), pp. 2012-2022
41 K.D. Meyer, D.P. Patil, J. Zhou, et al.5'UTR m(6)a promotes cap-independent translation Cell, 163 (4) (2015), pp. 999-1010
42 S. Ke, A. Pandya-Jones, Y. Saito, et al.m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover Genes Dev, 31 (10) (2017), pp. 990-1006
43 S. Sommer, U. Lavi, J.E. Darnell Jr.The absolute frequency of labeled N-6-methyladenosine in HeLa cell messenger RNA decreases with label time J Mol Biol, 124 (3) (1978), pp. 487-499
44 R.J. Ontiveros, H. Shen, J. Stoute, et al.Coordination of mRNA and tRNA methylations by TRMT10A Proc Natl Acad Sci U S A, 117 (14) (2020), pp. 7782-7791
45 C. Feng, Y. Liu, G. Wang, et al.Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition J Biol Chem, 289 (17) (2014), pp. 11571-11583
46 W. Aik, J.S. Scotti, H. Choi, et al.Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation Nucleic Acids Res, 42 (7) (2014), pp. 4741-4754
47 C. Xu, K. Liu, W. Tempel, et al.Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation J Biol Chem, 289 (25) (2014), pp. 17299-17311
48 Y. Ueda, I. Ooshio, Y. Fusamae, et al.AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells Sci Rep, 7 (2017), Article 42271
49 L.J. Xie, X.T. Yang, R.L. Wang, et al.Identification of flavin mononucleotide as a cell-active artificial N6-methyladenosine RNA demethylase Angew Chem Int Ed Engl, 58 (15) (2019), pp. 5028-5032
50 C.D. Allis, T. JenuweinThe molecular hallmarks of epigenetic control Nat Rev Genet, 17 (8) (2016), pp. 487-500
51 X. Wang, Z. Lu, A. Gomez, et al.N6-methyladenosine-dependent regulation of messenger RNA stability Nature, 505 (7481) (2014), pp. 117-120
52 H. Du, Y. Zhao, J. He, et al.YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex Nat Commun, 7 (2016), pp. 1-11
53 H. Shi, X. Wang, Z. Lu, et al.YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA Cell Res, 27 (3) (2017), pp. 315-328
54 P.J. Hsu, Y. Zhu, H. Ma, et al.Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis Cell Res, 27 (9) (2017), pp. 1115-1127
55 W. Xiao, S. Adhikari, U. Dahal, et al.Nuclear m6A reader YTHDC1 regulates mRNA splicing Mol Cell, 61 (4) (2016), pp. 507-519
56 I.A. Roundtree, G.Z. Luo, Z. Zhang, et al.YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs Elife, 6 (2017), Article e31311
57 C.R. Alarcón, H. Goodarzi, H. Lee, et al.HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events Cell, 162 (6) (2015), pp. 1299-1308
58 N. Liu, K.I. Zhou, M. Parisien, et al.N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein Nucleic Acids Res, 45 (10) (2017), pp. 6051-6063
59 N. Liu, Q. Dai, G. Zheng, et al.N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions Nature, 518 (7540) (2015), pp. 560-564
60 H. Huang, H. Weng, W. Sun, et al.Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation Nat Cell Biol, 20 (3) (2018), pp. 285-295
61 B. Yang, J.Q. Wang, Y. Tan, et al.RNA methylation and cancer treatment Pharmacol Res, 174 (2021), Article 105937
62 K.D. Meyer, D.P. Patil, J. Zhou, et al.5'UTR m6A promotes cap-independent translation Cell, 163 (4) (2015), pp. 999-1010
63 R. Wu, A. Li, B. Sun, et al.A novel m6A reader Prrc2a controls oligodendroglial specification and myelination Cell Res, 29 (1) (2019), pp. 23-41
64 R.R. Edupuganti, S. Geiger, R.G.H. Lindeboom, et al.N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis Nat Struct Mol Biol, 24 (10) (2017), pp. 870-878
65 F. Zhang, Y. Kang, M. Wang, et al.Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets Hum Mol Genet, 27 (22) (2018), pp. 3936-3950
66 M.G. Netea, L.A.B. Joosten, E. Latz, et al.Trained immunity: a program of innate immune memory in health and disease Science, 352 (6284) (2016), p. aaf1098
67 L. Tang, X. Wei, T. Li, et al.Emerging perspectives of RNA N6-methyladenosine (m6A) modification on immunity and autoimmune diseases Front Immunol, 12 (2021), Article 630358
68 S.K. Wculek, F.J. Cueto, A.M. Mujal, et al.Dendritic cells in cancer immunology and immunotherapy Nat Rev Immunol, 20 (1) (2020), pp. 7-24
69 D. Han, J. Liu, C. Chen, et al.Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells Nature, 566 (7743) (2019), pp. 270-274
70 H. Wang, X. Hu, M. Huang, et al.Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation Nat Commun, 10 (2019), p. 1898
71 H. Wu, Z. Xu, Z. Wang, et al.Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival Gene Immun, 21 (3) (2020), pp. 193-202
72 J. Liu, X. Zhang, K. Chen, et al.CCR7 chemokine receptor-inducible lnc-Dpf 3 restrains dendritic cell migration by inhibiting HIF-1α-mediated glycolysis Immunity, 50 (3) (2019), pp. 600-615.e15
73 P.J. Gong, Y.C. Shao, Y. Yang, et al.Analysis of N6-methyladenosine methyltransferase reveals METTL14 and ZC3H13 as tumor suppressor genes in breast cancer Front Oncol, 10 (2020), Article 578963
74 P.J. Murray, T.A. WynnProtective and pathogenic functions of macrophage subsets Nat Rev Immunol, 11 (11) (2011), pp. 723-737
75 X. Gu, Y. Zhang, D. Li, et al.N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation Cell Signal, 69 (2020), Article 109553
76 Y. Liu, Z. Liu, H. Tang, et al.The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA Am J Physiol Cell Physiol, 317 (4) (2019), pp. C762-C775
77 N. Huangfu, W. Zheng, Z. Xu, et al.RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis Int Immunopharm, 83 (2020), Article 106432
78 J. Tong, X. Wang, Y. Liu, et al.Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation Sci Adv, 7 (18) (2021), Article eabd4742
79 H. Lei, M. He, X. He, et al.METTL3 induces bone marrow mesenchymal stem cells osteogenic differentiation and migration through facilitating M1 macrophage differentiation Am J Transl Res, 13 (5) (2021), pp. 4376-4388
80 H. Yin, X. Zhang, P. Yang, et al.RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming Nat Commun, 12 (2021), p. 1394
81 G. Jia, X. Wang, W. Wu, et al.LXA4 enhances prostate cancer progression by facilitating M2 macrophage polarization via inhibition of METTL3 Int Immunopharm, 107 (2022), Article 108586
82 L. Dong, C. Chen, Y. Zhang, et al.The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth Cancer Cell, 39 (7) (2021), pp. 945-957 e10
83 J. Du, W. Liao, W. Liu, et al.N6-adenosine methylation of Socs 1 mRNA is required to sustain the negative feedback control of macrophage activation Dev Cell, 55 (6) (2020), pp. 737-753 e7
84 Y. Zheng, Y. Li, X. Ran, et al.Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway Cell Mol Life Sci, 79 (6) (2022), p. 311
85 X. Wang, Y. Ji, P. Feng, et al.The m6A reader IGF2BP2 regulates macrophage phenotypic activation and inflammatory diseases by stabilizing TSC1 and PPARγ Adv Sci, 8 (13) (2021), Article 2100209
86 E. Vivier, E. Tomasello, M. Baratin, et al.Functions of natural killer cells Nat Immunol, 9 (5) (2008), pp. 503-510
87 J. Parkin, B. CohenAn overview of the immune system Lancet, 357 (9270) (2001), pp. 1777-1789
88 H. Song, J. Song, M. Cheng, et al.METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells Nat Commun, 12 (2021), p. 5522
89 Y. Luo, Y. Sun, L. Li, et al.METTL3 may regulate testicular germ cell tumors through EMT and immune pathways Cell Transplant, 29 (2020), Article 963689720946653
90 Y. Zhou, S. Guo, Y. Li, et al.METTL3 is associated with the malignancy of esophageal squamous cell carcinoma and serves as a potential immunotherapy biomarker Front Oncol, 12 (2022), Article 824190
91 B.J. Kaskow, C. Baecher-AllanEffector T cells in multiple sclerosis Cold Spring Harb Perspect Med, 8 (4) (2018), p. a029025
92 M. Dominguez-Villar, D.A. HaflerRegulatory T cells in autoimmune disease Nat Immunol, 19 (7) (2018), pp. 665-673
93 H.B. Li, J. Tong, S. Zhu, et al.m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways Nature, 548 (7667) (2017), pp. 338-342
94 H. Chen, Y. Pan, Q. Zhou, et al.METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer Gastroenterology, 163 (4) (2022), pp. 891-907
95 T.X. Lu, Z. Zheng, L. Zhang, et al.A new model of spontaneous colitis in mice induced by deletion of an RNA m6A methyltransferase component METTL14 in T cells Cell Mol Gastroenterol Hepatol, 10 (4) (2020), pp. 747-761
96 J. Tong, G. Cao, T. Zhang, et al.m6A mRNA methylation sustains Treg suppressive functions Cell Res, 28 (2) (2018), pp. 253-256
97 H. Shi, C. Liu, H. Tan, et al.Hippo kinases Mst1 and Mst2 sense and amplify IL-2R-STAT5 signaling in regulatory T cells to establish stable regulatory activity Immunity, 49 (5) (2018), pp. 899-914 e6
98 N. Li, Y. Kang, L. Wang, et al.ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment Proc Natl Acad Sci U S A, 117 (33) (2020), pp. 20159-20170
99 J. Zhou, X. Zhang, J. Hu, et al.m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Sci Adv, 7 (25) (2021), Article eabg0470
100 W. Wan, X. Ao, Q. Chen, et al.METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer Mol Cancer, 21 (2022), p. 60
101 Y. Yao, Y. Yang, W. Guo, et al.METTL3-dependent m6A modification programs T follicular helper cell differentiation Nat Commun, 12 (2021), p. 1333
102 Y. Zhu, Y. Zhao, L. Zou, et al.The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control J Exp Med, 216 (7) (2019), pp. 1664-1681
103 T. Xu, S. Gao, H. Ruan, et al.METTL14 acts as a potential regulator of tumor immune and progression in clear cell renal cell carcinoma Front Genet, 12 (2021), Article 609174
104 Z. Zheng, L. Zhang, X.L. Cui, et al.Control of early B cell development by the RNA N6-methyladenosine methylation Cell Rep, 31 (13) (2020), Article 107819
105 X. Kang, S. Chen, L. Pan, et al.Deletion of Mettl3 at the pro-B stage marginally affects B cell development and profibrogenic activity of B cells in liver fibrosis J Immunol Res, 2022 (2022), Article 8118577
106 N.S. De Silva, U. KleinDynamics of B cells in germinal centres Nat Rev Immunol, 15 (3) (2015), pp. 137-148
107 J. Jacob, G. Kelsoe, K. Rajewsky, et al.Intraclonal generation of antibody mutants in germinal centres Nature, 354 (6352) (1991), pp. 389-392
108 A.C. Grenov, L. Moss, S. Edelheit, et al.The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers J Exp Med, 218 (10) (2021), Article e20210360
109 S. Finkin, H. Hartweger, T.Y. Oliveira, et al.Protein amounts of the MYC transcription factor determine germinal center B cell division capacity Immunity, 51 (2) (2019), pp. 324-336 e5
110 F.J. Weisel, S.J. Mullett, R.A. Elsner, et al.Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis Nat Immunol, 21 (3) (2020), pp. 331-342
111 M.G. Vander Heiden, L.C. Cantley, C.B. ThompsonUnderstanding the Warburg effect: the metabolic requirements of cell proliferation Science, 324 (5930) (2009), pp. 1029-1033
112 H. Huang, G. Zhang, G.X. Ruan, et al.Mettl14-mediated m6A modification is essential for germinal center B cell response J Immunol, 208 (8) (2022), pp. 1924-1936
113 Y. Cheng, Y. Fu, Y. Wang, et al.The m6A methyltransferase METTL3 is functionally implicated in DLBCL development by regulating m6A modification in PEDF Front Genet, 11 (2020), p. 955
114 H. Han, G. Fan, S. Song, et al.piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL Blood, 137 (12) (2021), pp. 1603-1614
115 Y. Wang, L. Li, J. Li, et al.The emerging role of m6A modification in regulating the immune system and autoimmune diseases Front Cell Dev Biol, 9 (2021), Article 755691
116 L. Durcan, T. O'Dwyer, M. PetriManagement strategies and future directions for systemic lupus erythematosus in adults Lancet, 393 (10188) (2019), pp. 2332-2343
117 G.C. TsokosSystemic lupus erythematosus N Engl J Med, 365 (22) (2011), pp. 2110-2121
118 J. Chen, W. Qu, L. Sun, et al.The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study Sci Rep, 11 (2021), Article 18591
119 G. Guo, H. Wang, X. Shi, et al.Disease activity-associated alteration of mRNA m5 C methylation in CD4+ T cells of systemic lupus erythematosus Front Cell Dev Biol, 8 (2020), p. 430
120 Q. Luo, J. Rao, L. Zhang, et al.The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus Mol Genet Genomic Med, 8 (9) (2020), p. e1298
121 K. Rajamäki, A. Taira, R. Katainen, et al.Genetic and epigenetic characteristics of inflammatory bowel disease-associated colorectal cancer Gastroenterology, 161 (2) (2021), pp. 592-607
122 D.P.B. McGovern, S. Kugathasan, J.H. ChoGenetics of inflammatory bowel diseases Gastroenterology, 149 (5) (2015), pp. 1163-1176 e2
123 F.J. Ryan, A.M. Ahern, R.S. Fitzgerald, et al.Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease Nat Commun, 11 (2020), p. 1512
124 M. Kaczmarek-Ryś, S.T. Hryhorowicz, E. LIS, et al.Crohn's disease susceptibility and onset are strongly related to three NOD2 gene haplotypes J Clin Med, 10 (17) (2021), p. 3777
125 C. Bolton, C.S. Smillie, S. Pandey, et al.An integrated taxonomy for monogenic inflammatory bowel disease Gastroenterology, 162 (3) (2022), pp. 859-876
126 X. Xu, J. Huang, D.K.W. Ocansey, et al.The emerging clinical application of m6A RNA modification in inflammatory bowel disease and its associated colorectal cancer J Inflamm Res, 14 (2021), pp. 3289-3306
127 L. Yang, G. Wu, Q. Wu, et al.METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice Cell Death Dis, 8 (2022), p. 62
128 A. Olazagoitia-Garmendia, L. Zhang, P. Mera, et al.Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells Gut, 71 (1) (2022), pp. 68-76
129 Y. Chen, J. Lei, S. Hem6A modification mediates mucosal immune microenvironment and therapeutic response in inflammatory bowel disease Front Cell Dev Biol, 9 (2021), Article 692160
130 M. Sebastian-delaCruz, A. Olazagoitia-Garmendia, I. Gonzalez-Moro, et al.Implication of m6A mRNA methylation in susceptibility to inflammatory bowel disease Epigenomes, 4 (3) (2020), p. 16
131 S. Klineova, F.D. LublinClinical course of multiple sclerosis Cold Spring Harb Perspect Med, 8 (9) (2018), Article a028928
132 M. Filippi, A. Bar-Or, F. Piehl, et al.Multiple sclerosis Nat Rev Dis Prim, 4 (1) (2018), p. 43
133 W. Kim, N.A. PatsopoulosGenetics and functional genomics of multiple sclerosis Semin Immunopathol, 44 (1) (2022), pp. 63-79
134 N. Celarain, J. Tomas-RoigAberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients J Neuroinflammation, 17 (2020), p. 21
135 X.B. Mo, S.F. Lei, Q.Y. Qian, et al.Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis J Neurol, 266 (11) (2019), pp. 2699-2709
136 Y. Zheng, P. Nie, D. Peng, et al.m6Avar: a database of functional variants involved in m6A modification Nucleic Acids Res, 46 (D1) (2018), pp. D139-D145
137 F. Ye, T. Wang, X. Wu, et al.N6-Methyladenosine RNA modification in cerebrospinal fluid as a novel potential diagnostic biomarker for progressive multiple sclerosis J Transl Med, 19 (2021), p. 316
138 W. Davis, S.J. van Rensburg, F.J. Cronje, et al.The fat mass and obesity-associated FTO rs9939609 polymorphism is associated with elevated homocysteine levels in patients with multiple sclerosis screened for vascular risk factors Metab Brain Dis, 29 (2) (2014), pp. 409-419
139 A. Al-Serri, R. Alroughani, R.A. Al-TemaimiThe FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients Sci Rep, 9 (2019), Article 19071
140 M.A. Gianfrancesco, M.M. Glymour, S. Walter, et al.Causal effect of genetic variants associated with body mass index on multiple sclerosis susceptibility Am J Epidemiol, 185 (3) (2017), pp. 162-171
141 J.S. Smolen, D. Aletaha, I.B. McInnesRheumatoid arthritis Lancet, 388 (10055) (2016), pp. 2023-2038
142 L. PadyukovGenetics of rheumatoid arthritis Semin Immunopathol, 44 (1) (2022), pp. 47-62
143 J. Wang, S. Yan, H. Lu, et al.METTL3 attenuates LPS-induced inflammatory response in macrophages via NF- κ B signaling pathway Mediat Inflamm, 2019 (2019), Article 3120391
144 Q. Liu, M. Li, L. Jiang, et al.METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte Biochem Biophys Res Commun, 516 (1) (2019), pp. 22-27
145 X.B. Mo, Y.H. Zhang, S.F. LeiGenome-wide identification of N6-methyladenosine (m6A) SNPs associated with rheumatoid arthritis Front Genet, 9 (2018), p. 299
146 Q. Luo, Y. Gao, L. Zhang, et al.Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis Biomed Res Int, 2020 (2020), Article 5735279
147 W.H. Boehncke, M.P. Schön Psoriasis. Lancet., 386 (9997) (2015), pp. 983-994
148 F. CaponThe genetic basis of psoriasis Int J Mol Sci, 18 (12) (2017), p. 2526
149 S. Thatikonda, V. Pooladanda, D.K. Sigalapalli, et al.Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation Cell Death Dis, 11 (1) (2020), p. 21
150 K. Dopytalska, P. Ciechanowicz, K. Wiszniewski, et al.The role of epigenetic factors in psoriasis Int J Mol Sci, 22 (17) (2021), p. 9294
151 K. Gervin, M.D. Vigeland, M. Mattingsdal, et al.DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes PLoS Genet, 8 (1) (2012), Article e1002454
152 Y.N. Wang, H.Z. JinTranscriptome-wide m6A methylation in skin lesions from patients with psoriasis vulgaris Front Cell Dev Biol, 8 (2020), Article 591629
153 A. Katsarou, S. Gudbjörnsdottir, A. Rawshani, et al.Type 1 diabetes mellitus Nat Rev Dis Prim, 3 (2017), Article 17016
154 M. Bakay, R. Pandey, S.F.A. Grant, et al.The genetic contribution to type 1 diabetes Curr Diabetes Rep, 19 (11) (2019), p. 116
155 S.F. Field, J.M. Howson, N.M. Walker, et al.Analysis of the obesity gene FTO in 14, 803 type 1 diabetes cases and controls Diabetologia, 50 (10) (2007), pp. 2218-2220
156 R. Hjort, J.E. Löfvenborg, E. Ahlqvist, et al.Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes J Clin Endocrinol Metab, 104 (10) (2019), pp. 4815-4826
157 M. Li, X. Zhong, Z. Zhao, et al.The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1 Brain Res, 1777 (2022), Article 147766
158 W. Xie, L.L. Ma, Y.Q. Xu, et al.METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism Biochem Biophys Res Commun, 518 (1) (2019), pp. 120-126
159 S. Saevarsdottir, T.A. Olafsdottir, E.V. Ivarsdottir, et al.FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease Nature, 584 (7822) (2020), pp. 619-623
160 R.H. Song, J. Zhao, C.Q. Gao, et al.Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease Adv Med Sci, 66 (2) (2021), pp. 351-358
161 R.H. Song, P. Du, C.Q. Gao, et al.METTL3 is involved in the development of Graves' disease by inducing SOCS mRNA m6A modification Front Endocrinol, 12 (2021), Article 666393
162 N.E. GilhusMyasthenia gravis N Engl J Med, 375 (26) (2016), pp. 2570-2581
163 S. Thomas, O.M. Fayet, F. Truffault, et al.Altered expression of fragile X mental retardation-1 (FMR1) in the thymus in autoimmune myasthenia gravis J Neuroinflammation, 18 (2021), p. 270
164 D. van der Heijde, I.H. Song, A.L. Pangan, et al.Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial Lancet, 394 (10214) (2019), pp. 2108-2117
165 Z. Xie, W. Yu, G. Zheng, et al.TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis Nat Commun, 12 (2021), p. 5373
166 S.T. Crooke, J.L. Witztum, C.F. Bennett, et al.RNA-targeted therapeutics Cell Metabol, 29 (2) (2019), p. 501
167 Y. Qiao, B. Zhou, M. Zhang, et al.A novel inhibitor of the obesity-related protein FTO Biochemistry, 55 (10) (2016), pp. 1516-1522
168 S. Peng, W. Xiao, D. Ju, et al.Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1 Sci Transl Med, 11 (488) (2019), Article eaau7116
169 R. Wang, Z. Han, B. Liu, et al.Identification of natural compound radicicol as a potent FTO inhibitor Mol Pharm, 15 (9) (2018), pp. 4092-4098
170 W. He, B. Zhou, W. Liu, et al.Identification of A novel small-molecule binding site of the fat mass and obesity associated protein (FTO) J Med Chem, 58 (18) (2015), pp. 7341-7348
171 Y. Huang, J. Yan, Q. Li, et al.Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 Nucleic Acids Res, 43 (1) (2015), pp. 373-384
172 R.K. Bedi, D. Huang, S.A. Eberle, et al.Small-molecule inhibitors of METTL3, the major human epitranscriptomic writer ChemMedChem, 15 (9) (2020), pp. 744-748
173 B. Chen, F. Ye, L. Yu, et al.Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor J Am Chem Soc, 134 (43) (2012), pp. 17963-17971
174 R. Su, L. Dong, C. Li, et al.R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling Cell, 172 (1–2) (2018), pp. 90-105 e23
175 K. Liu, Q.Y. Ouyang, Y. Zhan, et al.Pharmacoepitranscriptomic landscape revealing m6A modification could be a drug-effect biomarker for cancer treatment Mol Ther Nucleic Acids, 28 (2022), pp. 464-476
176 W. Zhang, L. He, Z. Liu, et al.Multifaceted functions and novel insight into the regulatory role of RNA N6-methyladenosine modification in musculoskeletal disorders Front Cell Dev Biol, 8 (2020), p. 870
0
Views
0
下载量
0
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
