Salvage treatment in <em>IDH1</em> mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report

Dan Li; Shuqi Zhao; Liping Mao; Jie Jin; Jinghan Wang

doi:10.1016/j.gendis.2023.02.011

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Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report

Short communication | 更新时间：2024-02-04

- Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report
- Genes & Diseases Vol. 1, Issue 6, Pages: 2215-2217(2023)
- 作者机构：
  
  1. Department of Hematology, Shaoxing People's Hospital,Zhejiang,Shaoxing,China,312000
  2. Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine,Zhejiang,Hangzhou,China,310003
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.011
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Dan Li, Shuqi Zhao, Liping Mao, et al. Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report. [J]. Genes & Diseases 1(6):2215-2217(2023)
DOI：

Dan Li, Shuqi Zhao, Liping Mao, et al. Salvage treatment in IDH1 mutated acute lymphoblastic leukemia with venetoclax plus methotrexate and pegaspargase: A case report. [J]. Genes & Diseases 1(6):2215-2217(2023) DOI： 10.1016/j.gendis.2023.02.011.

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1 T. Yasuda, M. Sanada, M. Kawazu, et al.Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations Blood, 139 (12) (2022), pp. 1850-1862

2 C.L. Jones, B.M. Stevens, D.A. Pollyea, et al.Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells Cell Stem Cell, 27 (5) (2020), pp. 748-764.e4

3 C.L. Jones, B.M. Stevens, A. D'Alessandro, et al.Inhibition of amino acid metabolism selectively targets human leukemia stem cells Cancer Cell, 34 (5) (2018), pp. 724-740.e4

4 A. Emadi, B. Kapadia, D. Bollino, et al.Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia Leukemia, 35 (7) (2021), pp. 1907-1924

5 W.H. Tong, R. Pieters, W.C.J. Hop, et al.No evidence of increased asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy Pediatr Blood Cancer, 60 (2) (2013), pp. 258-261

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