Targeted down-regulation of <em>Hipp1</em> ameliorates tau-induced deficits in <em>Drosophila melanogaster</em>

Sung Yeon Park; Jieun Seo; Seulbee Lee; Joohyung Kim; Sang Jeong Kim; Seungbok Lee; Yang-Sook Chun

doi:10.1016/j.gendis.2023.02.009

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Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster

Short communication | 更新时间：2024-02-04

- Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster
- Genes & Diseases Vol. 1, Issue 6, Pages: 2248-2251(2023)
- 作者机构：
  
  1. Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
  2. Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
  3. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
  4. Department of Brain and Cognitive Sciences, Seoul National University, Seoul 08826, Republic of Korea
  5. Department of Cell and Developmental Biology and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.009
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Sung Yeon Park, Jieun Seo, Seulbee Lee, et al. Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster. [J]. Genes & Diseases 1(6):2248-2251(2023)
DOI：

Sung Yeon Park, Jieun Seo, Seulbee Lee, et al. Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster. [J]. Genes & Diseases 1(6):2248-2251(2023) DOI： 10.1016/j.gendis.2023.02.009.

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1 V.M. Lee, M. Goedert, J.Q. TrojanowskiNeurodegenerative tauopathies Annu Rev Neurosci, 24 (2001), pp. 1121-1159

2 B. Frost, M. Hemberg, J. Lewis, et al.Tau promotes neurodegeneration through global chromatin relaxation Nat Neurosci, 17 (3) (2014), pp. 357-366

3 A.A. Alekseyenko, A.A. Gorchakov, B.M. Zee, et al.Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs Genes Dev, 28 (13) (2014), pp. 1445-1460

4 Y.B. Schwartz, G. CavalliThree-dimensional genome organization and function in Drosophila Genetics, 205 (1) (2017), pp. 5-24

5 Y.B. Schwartz, D. Linder-Basso, P.V. Kharchenko, et al.Nature and function of insulator protein binding sites in the Drosophila genome Genome Res, 22 (11) (2012), pp. 2188-2198

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