The essential roles of m6A modification in osteogenesis and common bone diseases
- Genes & Diseases Vol. 1, Issue 1, Pages: 335-345(2024)
- 作者机构：
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
DOI：10.1016/j.gendis.2023.01.032
CLC：Published：2024，
Published Online：1 January 2024，
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Yuxi Gu, Yidan Song, Yihua Pan, et al. The essential roles of m6A modification in osteogenesis and common bone diseases. [J]. Genes & Diseases 1(1):335-345(2024)
Yuxi Gu, Yidan Song, Yihua Pan, et al. The essential roles of m6A modification in osteogenesis and common bone diseases. [J]. Genes & Diseases 1(1):335-345(2024) DOI： 10.1016/j.gendis.2023.01.032.
摘要
Abstract
N6-methyladenosine (m
6
A) is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding RNAs. It affects the fate of the modified RNA
including its stability
splicing
and translation
and plays an important role in post-transcriptional regulation. Bones play a key role in supporting and protecting muscles and other organs
facilitating the movement of the organism
ensuring blood production
etc
. Bone diseases such as osteoarthritis
osteoporosis
and bone tumors are serious public health problems. The processes of bone development and osteogenic differentiation require the precise regulation of gene expression through epigenetic mechanisms including histone
DNA
and RNA modifications. As a reversible dynamic epigenetic mark
m
6
A modifications affect nearly every important biological process
cellular component
and molecular function
including skeletal development and homeostasis. In recent years
studies have shown that m
6
A modification is involved in osteogenesis and bone-related diseases. In this review
we summarized the proteins involved in RNA m
6
A modification and the latest progress in elucidating the regulatory role of m
6
A modification in bone formation and stem cell directional differentiation. We also discussed the pathological roles and potential molecular mechanisms of m
6
A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone defects and bone diseases.
关键词
Keywords
Bone diseasesm6A modificationOsteogenesisRegulatory roleStem cells
references
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