1. Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago,IL,USA,60064
2. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
3. Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University,Chongqing,China,400016
4. Departments of Orthopaedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
5. Department of Interventional Neurology, The First Dongguan Affiliated Hospital, Guangdong Medical University,Guangdong,Dongguan,China,523475
6. Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine,Shanghai,China,200000
7. Laboratory of Craniofacial Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637
8. School of Biomedical Engineering, Vanderbilt University,TN,Nashville,USA,37235
Published:2024,
Published Online:1 January 2024,
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Kevin Qin, Michael Yu, Jiaming Fan, et al. Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk. [J]. Genes & Diseases 1(1):103-134(2024)
Kevin Qin, Michael Yu, Jiaming Fan, et al. Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk. [J]. Genes & Diseases 1(1):103-134(2024) DOI: 10.1016/j.gendis.2023.01.030.
Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body
establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems
including cancer and embryological defects
and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However
both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway
beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling
including canonical
noncanonical Wnt/PCP
and the noncanonical Wnt/Ca
2+
pathway. Further description involved each of its components and their involvement in other cellular processes. Finally
this review explained the various other pathways and processes that crosstalk with Wnt signaling.
β-cateninCanonical WntNoncanonical WntSignal transductionSignaling crosstalk
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