A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

Xinghui Li; Haiping Wang; Yandi Wu; Li Zou; Shijie Deng; Xinlu Fu; Tongsheng Huang; Conghui Shen; Teng Wu; Weibin Cai

doi:10.1016/j.gendis.2023.01.011

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A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

Short communication | 更新时间：2024-02-04

- A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis
- Genes & Diseases Vol. 1, Issue 1, Pages: 11-14(2024)
- 作者机构：
  
  1. Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University,Guangdong,Guangzhou,China,510080
  2. Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University,Guangdong,Guangzhou,China,510080
  3. School of Pharmacy, Guangdong Pharmaceutical University,Guangdong,Guangzhou,China,510006
  4. Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University,Guangdong,Shenzhen,China,518107
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.011
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Xinghui Li, Haiping Wang, Yandi Wu, et al. A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis. [J]. Genes & Diseases 1(1):11-14(2024)
DOI：

Xinghui Li, Haiping Wang, Yandi Wu, et al. A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis. [J]. Genes & Diseases 1(1):11-14(2024) DOI： 10.1016/j.gendis.2023.01.011.

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1 A. Asgharpour, S.C. Cazanave, T. Pacana, et al.A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer J Hepatol, 65 (3) (2016), pp. 579-588

2 T. Tsuchida, Y.A. Lee, N. Fujiwara, et al.A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer J Hepatol, 69 (2) (2018), pp. 385-395

3 K.T. Huang, K.D. Chen, L.W. Hsu, et al.Decreased PEDF promotes hepatic fatty acid uptake and lipid droplet formation in the pathogenesis of NAFLD Nutrients, 12 (1) (2020), p. 270

4 S. Niyogi, M. Ghosh, M. Adak, et al.PEDF promotes nuclear degradation of ATGL through COP1 Biochem Biophys Res Commun, 512 (4) (2019), pp. 806-811

5 M.M. Véniant, S. Withycombe, S.G. YoungLipoprotein size and atherosclerosis susceptibility in Apoe (-/-) and Ldlr (-/-) mice Arterioscler Thromb Vasc Biol, 21 (10) (2001), pp. 1567-1570

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