Cell Biology Department, ICMR-National Institute of Nutrition (NIN),, Telangana,Hyderabad,India,500007
Published:2024,
Published Online:1 January 2024,
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Divya Ajmeera, Rajanna Ajumeera. Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance. [J]. Genes & Diseases 1(1):148-175(2024)
Divya Ajmeera, Rajanna Ajumeera. Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance. [J]. Genes & Diseases 1(1):148-175(2024) DOI: 10.1016/j.gendis.2022.12.013.
Chemotherapy is an effortless and frequently used approach in cancer therapy. However
in most cases
it can only prolong life expectancy and does not guarantee a complete cure. Furthermore
chemotherapy is associated with severe adverse effects
one of the major complications of effective cancer therapy. In addition
newly published research outputs show that cancer stem cells are involved in cancer disease progression
drug resistance
metastasis
and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments. Novel strategies are therefore required for better management of cancer therapy. The prime approach would be to synthesize and develop novel drugs that need extensive resources
time
and endurance to be brought into therapeutic use. The subsequent approach would be to screen the anti-cancer activity of available non-cancerous drugs. This concept of repurposing non-cancer drugs as an alternative to current cancer therapy has become popular in recent years because using existing anticancer drugs has several adverse effects. Micronutrients have also been investigated for cancer therapy due to their significant anti-cancer effects with negligible or no side effects and availability in food sources. In this paper
we discuss an ideal hypothesis for screening available non-cancerous drugs with anticancer activity
with a focus on cancer stem cells and their clinical application for cancer treatment. Further
drug repurposing and the combination of micronutrients that can target both cancers and cancer stem cells may result in a better therapeutic approach leading to maximum tumor growth control.
Cancer stem cellsChemotherapyCombination therapy micronutrientsNon-cancer drugsNovel strategies
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