Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Haochen Wang; Hui Yu; Tianyu Huang; Bin Wang; Lin Xiang

doi:10.1016/j.gendis.2022.12.012

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Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Review article | 更新时间：2024-02-04

- Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair
- Genes & Diseases Vol. 1, Issue 6, Pages: 2528-2539(2023)
- 作者机构：
  
  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
  2. Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.12.012
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Haochen Wang, Hui Yu, Tianyu Huang, et al. Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair. [J]. Genes & Diseases 1(6):2528-2539(2023)
DOI：

Haochen Wang, Hui Yu, Tianyu Huang, et al. Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair. [J]. Genes & Diseases 1(6):2528-2539(2023) DOI： 10.1016/j.gendis.2022.12.012.

摘要

Abstract

Bone defects caused by diseases or surgery are a common clinical problem. Researchers are devoted to finding biological mechanisms that accelerate bone defect repair

which is a complex and continuous process controlled by many factors. As members of transcriptional costimulatory molecules

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play an important regulatory role in osteogenesis

and they affect cell function by regulating the expression of osteogenic genes in osteogenesis-related cells. Macrophages are an important group of cells whose function is regulated by YAP/TAZ. Currently

the relationship between YAP/TAZ and macrophage polarization has attracted increasing attention. In bone tissue

YAP/TAZ can realize diverse osteogenic regulation by mediating macrophage polarization. Macrophages polarize into M1 and M2 phenotypes under different stimuli. M1 macrophages dominate the inflammatory response by releasing a number of inflammatory mediators in the early phase of bone defect repair

while massive aggregation of M2 macrophages is beneficial for inflammation resolution and tissue repair

as they secrete many anti-inflammatory and osteogenesis-related cytokines. The mechanism of YAP/TAZ-mediated macrophage polarization during osteogenesis warrants further study and it is likely to be a promising strategy for bone defect repair. In this article

we review the effect of Hippo-YAP/TAZ signaling and macrophage polarization on bone defect repair

and highlight the regulation of macrophage polarization by YAP/TAZ.

关键词

Keywords

Bone defect repairHippo-YAP/TAZ signalingInflammationMacrophage polarizationOsteogenesis

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Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences

Department of Biosciences, Jamia Millia Islamia University

School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport

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