1. Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou,China,450052
2. Academy of Medical Sciences of Zhengzhou University,Henan,Zhengzhou,China,450001
3. Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital,Henan,Zhengzhou,China,450008
4. Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou,China,450052
5. Department of Radiotherapy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital,Henan,Zhengzhou,China,450008
6. The First Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou,China,450052
Published:2024,
Published Online:1 January 2024,
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Zhuang Chen, Qiming Wang, Jinbo Liu, et al. Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression. [J]. Genes & Diseases 1(1):176-188(2024)
Zhuang Chen, Qiming Wang, Jinbo Liu, et al. Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression. [J]. Genes & Diseases 1(1):176-188(2024) DOI: 10.1016/j.gendis.2022.12.011.
pre-metastatic niche (PMN) is a protective microenvironment that facilitates the colonization of disseminating tumor cells in future metastatic organs. Extracellular vesicles (EVs) play a role in intercellular communication by delivering cargoes
such as noncoding RNAs (ncRNAs). The pivotal role of extracellular vesicle-derived noncoding RNAs (EV-ncRNAs) in the PMN has attracted increasing attention. In this review
we summarized the effects of EV-ncRNAs on the PMN in terms of immunosuppression
vascular permeability and angiogenesis
inflammation
metabolic reprogramming
and fibroblast alterations. In particular
we provided a comprehensive overview of the effects of EV-ncRNAs on the PMN in different cancers. Finally
we discussed the promising clinical applications of EV-ncRNAs
including their potential as diagnostic and prognostic markers and therapeutic targets.
BiomarkerExtracellular vesiclesNoncoding RNAsPre-metastatic nicheTumor progression
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