1. School of Life Sciences and Medicine, Shandong University of Technology,Shandong,Zibo,China,255000
2. Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University,Shanghai,China,200092
Published:2024,
Published Online:1 January 2024,
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Pengcheng Zhao, Longyan Xie, Lei Yu, et al. Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy. [J]. Genes & Diseases 1(1):205-217(2024)
Pengcheng Zhao, Longyan Xie, Lei Yu, et al. Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy. [J]. Genes & Diseases 1(1):205-217(2024) DOI: 10.1016/j.gendis.2022.12.008.
The interaction between cluster of differentiation 47 (CD47) and signal regulatory protein α (SIRPα) protects healthy cells from macrophage attack
which is crucial for maintaining immune homeostasis. Overexpression of CD47 occurs widely across various tumor cell types and transmits the “don't eat me” signal to macrophages to avoid phagocytosis through binding to SIRPα. Blockade of the CD47-SIRPα axis is therefore a promising approach for cancer treatment. Lymphoma is the most common hematological malignancy and is an area of unmet clinical need. This review mainly described the current strategies targeting the CD47-SIRPα axis
including antibodies
SIRPα Fc fusion proteins
small molecule inhibitors
and peptides both in preclinical studies and clinical trials with Hodgkin lymphoma and non-Hodgkin lymphoma.
Cancer treatmentCD47-SIRPα axisHodgkin lymphomaImmunotherapyNon-Hodgkin lymphoma
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