BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

Zhenhai Li; Wenchao Xu; Feng Chen; Jun Zhang; Wei-Guo Zhu

doi:10.1016/j.gendis.2022.12.001

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BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

Short communication | 更新时间：2024-02-04

- BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
- Genes & Diseases Vol. 1, Issue 1, Pages: 19-22(2024)
- 作者机构：
  
  1. Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine,Guangdong,Shenzhen,China,518055
  2. School of Pharmaceutical Sciences, Shenzhen University Health Science Center,Guangdong,Shenzhen,China,518055
  3. Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University Health Science Center,Guangdong,Shenzhen,China,518055
  4. Shenzhen Bay Laboratory, Shenzhen University School of Medicine,Guangdong,Shenzhen,China,518055
  5. Marshall Laboratory of Biomedical Engineering, Shenzhen University School of Medicine,Guangdong,Shenzhen,China,518055
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.12.001
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Zhenhai Li, Wenchao Xu, Feng Chen, et al. BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response. [J]. Genes & Diseases 1(1):19-22(2024)
DOI：

Zhenhai Li, Wenchao Xu, Feng Chen, et al. BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response. [J]. Genes & Diseases 1(1):19-22(2024) DOI： 10.1016/j.gendis.2022.12.001.

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1 F. Spriano, A. Stathis, F. BertoniTargeting BET bromodomain proteins in cancer: the example of lymphomas Pharmacol Ther, 215 (2020), Article 107631

2 N. Bennardo, A. Cheng, N. Huang, et al.Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair PLoS Genet, 4 (6) (2008), Article e1000110

3 A.J. Pierce, R.D. Johnson, L.H. Thompson, et al.XRCC3 promotes homology-directed repair of DNA damage in mammalian cells Genes Dev, 13 (20) (1999), pp. 2633-2638

4 W.R. Greco, G. Bravo, J.C. ParsonsThe search for synergy: a critical review from a response surface perspective Pharmacol Rev, 47 (2) (1995), pp. 331-385

5 P. Filippakopoulos, J. Qi, S. Picaud, et al.Selective inhibition of BET bromodomains Nature, 468 (7327) (2010), pp. 1067-1073

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