Epigenetic regulation of mesenchymal stem cell aging through histone modifications

Yanping Sun; Haoyu Zhang; Tao Qiu; Li Liao; Xiaoxia Su

doi:10.1016/j.gendis.2022.10.030

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Epigenetic regulation of mesenchymal stem cell aging through histone modifications

Review article | 更新时间：2024-02-04

- Epigenetic regulation of mesenchymal stem cell aging through histone modifications
- Genes & Diseases Vol. 1, Issue 6, Pages: 2443-2456(2023)
- 作者机构：
  
  State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatrics & Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.030
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Yanping Sun, Haoyu Zhang, Tao Qiu, et al. Epigenetic regulation of mesenchymal stem cell aging through histone modifications. [J]. Genes & Diseases 1(6):2443-2456(2023)
DOI：

Yanping Sun, Haoyu Zhang, Tao Qiu, et al. Epigenetic regulation of mesenchymal stem cell aging through histone modifications. [J]. Genes & Diseases 1(6):2443-2456(2023) DOI： 10.1016/j.gendis.2022.10.030.

摘要

Abstract

Stem cell senescence and exhaustion

a hallmark of aging

lead to declines in tissue repair and regeneration in aged individuals. Emerging evidence has revealed that epigenetic regulation plays critical roles in the self-renew

lineage-commitment

survival

and function of stem cells. Moreover

epigenetic alterations are considered important drivers of stem cell dysfunction during aging. In this review

we focused on current knowledge of the histone modifications in the aging of mesenchymal stem cells (MSCs). The aberrant epigenetic modifications on histones

including methylation and acetylation

have been found in aging MSCs. By disturbing the expression of specific genes

these epigenetic modifications affect the self-renew

survival

and differentiation of MSCs. A set of epigenetic enzymes that write or erase these modifications are critical in regulating the aging of MSCs. Furthermore

we discussed the rejuvenation strategies based on epigenetics to prevent stem cell aging and/or rejuvenate senescent MSCs.

关键词

Keywords

AgingEpigeneticHistone acetylationHistone methylationMesenchymal stem cell

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