New insights into the suppression of inflammation and lipid accumulation by <em>JAZF1</em>

Wujun Chen; Yingjie Zhong; Yang Yuan; Meng Zhu; Wenchao Hu; Ning Liu; Dongming Xing

doi:10.1016/j.gendis.2022.10.029

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New insights into the suppression of inflammation and lipid accumulation by JAZF1

Review article | 更新时间：2024-02-04

- New insights into the suppression of inflammation and lipid accumulation by JAZF1
- Genes & Diseases Vol. 1, Issue 6, Pages: 2457-2469(2023)
- 作者机构：
  
  1. Cancer Institute, Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute,Shandong,Qingdao,China,266071
  2. Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University,Shandong,Qingdao,China,266035
  3. School of Life Sciences, Tsinghua University,Beijing,China,100084
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.029
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Wujun Chen, Yingjie Zhong, Yang Yuan, et al. New insights into the suppression of inflammation and lipid accumulation by JAZF1. [J]. Genes & Diseases 1(6):2457-2469(2023)
DOI：

Wujun Chen, Yingjie Zhong, Yang Yuan, et al. New insights into the suppression of inflammation and lipid accumulation by JAZF1. [J]. Genes & Diseases 1(6):2457-2469(2023) DOI： 10.1016/j.gendis.2022.10.029.

摘要

Abstract

herosclerosis is one of the leading causes of disease and death worldwide. The identification of new therapeutic targets and agents is critical.

JAZF1

is expressed in many tissues and is found at particularly high levels in adipose tissue (AT).

JAZF1

suppresses inflammation (including

IL-1β

IL-4

IL-6

IL-8

IL-10

TNFα

IFN-γ

IAR-20

COL3A1

laminin

and

MCP-1

) by reducing

NF-κB

pathway activation and AT immune cell infiltration.

JAZF1

reduces lipid accumulation by regulating the liver X receptor response element (

LXRE

) of the

SREBP-1c

promoter

the

cAMP

-response element (

CRE

) of

HMGCR

and the

TR4

axis.

LXRE

and

CRE

sites are present in many cytokine and lipid metabolism gene promoters

which suggests that

JAZF1

regulates these genes through these sites.

NF-κB

is the center of the

JAZF1

-mediated inhibition of the inflammatory response.

JAZF1

suppresses

NF-κB

expression by suppressing

TAK1

expression. Interestingly

TAK1

inhibition also decreases lipid accumulation. A dual-targeting strategy of

NF-κB

and

TAK1

could inhibit both inflammation and lipid accumulation. Dual-target compounds (including prodrugs) 1–5 exhibit nanomolar inhibition by targeting

NF-κB

and

TAK1

EGFR

COX-2

. However

the

NF-κB

suppressing activity of these compounds is relatively low (IC

300 nM). Compounds 6–14 suppress

NF-κB

expression with IC

values ranging from 1.8 nM to 38.6 nM. HS-276 is a highly selective

orally bioavailable

TAK1

inhibitor. Combined structural modifications of compounds using a prodrug strategy may enhance

NF-κB

inhibition. This review focused on the role and mechanism of

JAZF1

in inflammation and lipid accumulation for the identification of new anti-atherosclerotic targets.

关键词

Keywords

AtherosclerosisCREJAZF1LXRENF-κBTAK1

references

1 Z. Yang, G.L. Yu, X. Zhu, et al.Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders Genes Dis, 9 (1) (2022), pp. 51-61

2 Q. Jiang, Y. Li, Q. Wu, et al.Pathogenic role of microRNAs in atherosclerotic ischemic stroke: implications for diagnosis and therapy Genes Dis, 9 (3) (2022), pp. 682-696

3 W. Chen, L. Li, J. Wang, et al.The ABCA1-efferocytosis axis: a new strategy to protect against atherosclerosis Clin Chim Acta, 518 (2021), pp. 1-8

4 W. Chen, S. Wang, D. XingNew horizons for the roles and association of APE1/Ref-1 and ABCA1 in atherosclerosis J Inflamm Res, 14 (2021), pp. 5251-5271

5 W. Chen, J. Xing, X. Liu, et al.The role and transformative potential of IL-19 in atherosclerosis Cytokine Growth Factor Rev, 62 (2021), pp. 70-82

6 W. Chen, Y. Zhong, N. Feng, et al.New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases Mol Med, 27 (1) (2021), p. 123

7 S. Zhang, L. Li, J. Wang, et al.Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs Clin Chim Acta, 516 (2021), pp. 100-110

8 M. Bäck, A. Yurdagul Jr., I. Tabas, et al.Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities Nat Rev Cardiol, 16 (7) (2019), pp. 389-406

9 Y. Hu, J. Wu, G. ZengCurrent research progress of JAZF1 in atherosclerosis J Mil Surgeon Southwest China, 23 (2) (2021), pp. 131-133

10 J. Jeong, S. Jang, S. Park, et al.JAZF1 heterozygous knockout mice show altered adipose development and metabolism Cell Biosci, 11 (1) (2021), p. 161

11 Y. Liang, M. Wang, C. Wang, et al.The mechanisms of the development of atherosclerosis in prediabetes Int J Mol Sci, 22 (8) (2021), p. 4108

12 S.H. Chou, J.M. Shulman, B.T. Keenan, et al.Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations Cerebrovasc Dis, 36 (3) (2013), pp. 181-188

13 Q. Wei, B. Zhou, G. Yang, et al.JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c-dependent mechanism Cell Death Dis, 9 (9) (2018), p. 859

14 M. Yang, J. Dai, Y. Jia, et al.Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB FEBS J, 281 (14) (2014), pp. 3193-3205

15 X. Li, M. Yang, H. Wang, et al.Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms Int J Cardiol, 177 (1) (2014), pp. 100-110

16 K.B. Bae, M.O. Kim, D.H. Yu, et al.Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice Transgenic Res, 20 (5) (2011), pp. 1019-1031

17 W. Dai, X. Liu, H. Su, et al.Influence of adipose tissue immune dysfunction on childhood obesity Cytokine Growth Factor Rev, 65 (2022), pp. 27-38

18 K. Shabir, J.E. Brown, I. Afzal, et al.Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: comprehensive review of preclinical and clinical evidence Cytokine Growth Factor Rev, 60 (2021), pp. 120-132

19 Z.Z. Liao, Y.D. Wang, X.Y. Qi, et al.JAZF1, a relevant metabolic regulator in type 2 diabetes Diabetes Metab Res Rev, 35 (5) (2019), p. e3148

20 R. Liu, Z. Lin, Y. Jia, et al.Effects of JAZF1 overexpression on proinflammatory cytokines in hepatocytes induced by palmitic acid Chin J Hepatol, 23 (12) (2015), pp. 950-954

21 W.J. Hu, W.W. Shen, X.J. Li, et al.Effect of JAZF1 over-expression on high-fat diet-induced non-alcoholic fatty liver disease Chin J Hepatol, 24 (8) (2016), pp. 596-600

22 E. Martynova, A. Rizvanov, R.A. Urbanowicz, et al.Inflammasome contribution to the activation of Th1, Th2, and Th17 immune responses Front Microbiol, 13 (2022), Article 851835

23 N. Thalayasingam, N. Nair, A.J. Skelton, et al.CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in patients with untreated early arthritis: implications for causal gene identification Arthritis Rheumatol, 70 (3) (2018), pp. 361-370

24 F. Meng, Y. Lin, M. Yang, et al.JAZF1 inhibits adipose tissue macrophages and adipose tissue inflammation in diet-induced diabetic mice BioMed Res Int, 2018 (2018), Article 4507659

25 F. Meng, P. Hao, H. Du, et al.Effects of adenovirus-mediated overexpression of JAZF1 on chronic inflammation: an in vitro and in vivo study Med Sci Monit Basic Res, 26 (2020), Article e924124

26 X. Ma, Q. Wang, Y. Liu, et al.Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production Int J Cancer, 136 (4) (2015), pp. 771-783

27 B. Samten, J.C. Townsend, S.E. Weis, et al.CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen J Immunol, 181 (3) (2008), pp. 2056-2064

28 C.H. Wu, C.T. Yeh, P.H. Shih, et al.Dietary phenolic acids attenuate multiple stages of protein glycation and high-glucose-stimulated proinflammatory IL-1beta activation by interfering with chromatin remodeling and transcription in monocytes Mol Nutr Food Res, 54 (Suppl 2) (2010), pp. S127-S140

29 T.J. Sisk, T. Gourley, S. Roys, et al.MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300 J Immunol, 165 (5) (2000), pp. 2511-2517

30 G.L. Lee, Y.W. Chang, J.Y. Wu, et al.TLR 2 induces vascular smooth muscle cell migration through cAMP response element-binding protein-mediated interleukin-6 production Arterioscler Thromb Vasc Biol, 32 (11) (2012), pp. 2751-2760

31 V. Iourgenko, W. Zhang, C. Mickanin, et al.Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells Proc Natl Acad Sci U S A, 100 (21) (2003), pp. 12147-12152

32 O. Ernst, Y. Glucksam-Galnoy, B. Bhatta, et al.Exclusive temporal stimulation of IL-10 expression in LPS-stimulated mouse macrophages by cAMP inducers and type I interferons Front Immunol, 10 (2019), p. 1788

33 B.M. Brinkman, J.B. Telliez, A.R. Schievella, et al.Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression J Biol Chem, 274 (43) (1999), pp. 30882-30886

34 H.C. Tsai, S. Velichko, S. Lee, et al.Cholera toxin enhances interleukin-17A production in both CD4+ and CD8+ cells via a cAMP/protein kinase A-mediated interleukin-17A promoter activation Immunology, 154 (3) (2018), pp. 500-509

35 P. Kumar, K. Natarajan, N. ShanmugamHigh glucose driven expression of pro-inflammatory cytokine and chemokine genes in lymphocytes: molecular mechanisms of IL-17 family gene expression Cell Signal, 26 (3) (2014), pp. 528-539

36 D. Nakladal, J.W.A. Sijbesma, L.M. Visser, et al.Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats Vasc Pharmacol, 142 (2022), Article 106945

37 R. Poledne, I. Králová LesnáAdipose tissue macrophages and atherogenesis - a synergy with cholesterolaemia Physiol Res, 70 (Suppl4) (2021), pp. S535-S549

38 C.F. Tsai, G.W. Chen, Y.C. Chen, et al.Regulatory effects of quercetin on M1/M2 macrophage polarization and oxidative/antioxidative balance Nutrients, 14 (1) (2021), p. 67

39 S. Kauerova, H. Bartuskova, B. Muffova, et al.Statins directly influence the polarization of adipose tissue macrophages: a role in chronic inflammation Biomedicines, 9 (2) (2021), p. 211

40 S. Ivanov, J. Merlin, M.K.S. Lee, et al.Biology and function of adipose tissue macrophages, dendritic cells and B cells Atherosclerosis, 271 (2018), pp. 102-110

41 L. Wang, P. Sun, Y. Wu, et al.Metabolic tissue-resident CD8+ T cells: a key player in obesity-related diseases Obes Rev, 22 (3) (2021), Article e13133

42 X. Peng, C. Feng, X. Wang, et al.Chemical composition and antioxidant activity of essential oils from barks of Pinus pumila using microwave-assisted hydrodistillation after screw extrusion treatment Ind Crop Prod, 166 (2021), Article 113489

43 K.A. Harford, C.M. Reynolds, F.C. McGillicuddy, et al.Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue Proc Nutr Soc, 70 (4) (2011), pp. 408-417

44 Q. Wang, Y. Wang, D. XuThe roles of T cells in obese adipose tissue inflammation Adipocyte, 10 (1) (2021), pp. 435-445

45 N. Alkhouri, E. Lawitz, M. Noureddin, et al.GS-0976 (Firsocostat):an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH) Expet Opin Invest Drugs, 29 (2) (2020), pp. 135-141

46 Monroig Ó, A.C. Shu-Chien, N. Kabeya, et al.Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: from genes to functions Prog Lipid Res, 86 (2022), Article 101157

47 R. Schreiber, H. Xie, M. SchweigerOf mice and men: the physiological role of adipose triglyceride lipase (ATGL) Biochim Biophys Acta Mol Cell Biol Lipids, 1864 (6) (2019), pp. 880-899

48 K.S. Jadhav, R.C. BauerTrouble with tribbles-1 Arterioscler Thromb Vasc Biol, 39 (6) (2019), pp. 998-1005

49 M. Haider, F. Al-Rashed, Z. Albaqsumi, et al.Candida albicans induces foaming and inflammation in macrophages through FABP4:its implication for atherosclerosis Biomedicines, 9 (11) (2021), p. 1567

50 L. Xu, H. Zhang, Y. Wang, et al.FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE-/- mice atherosclerosis Lab Invest, 102 (1) (2022), pp. 25-37

51 P. Ferré, F. FoufelleSREBP-1c transcription factor and lipid homeostasis: clinical perspective Horm Res, 68 (2) (2007), pp. 72-82

52 P. Cohen, J.M. FriedmanLeptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1) J Nutr, 134 (9) (2004), pp. 2455S-2463S

53 A.D. Lampidonis, E. Rogdakis, G.E. Voutsinas, et al.The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis Gene, 477 (1–2) (2011), pp. 1-11

54 G.F. Ming, D. Xiao, W.J. Gong, et al.JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes Biochem Biophys Res Commun, 445 (3) (2014), pp. 673-680

55 L. Li, Y. Yang, G. Yang, et al.The role of JAZF1 on lipid metabolism and related genes in vitro Metabolism, 60 (4) (2011), pp. 523-530

56 W.Y. Jang, K.B. Bae, S.H. Kim, et al.Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet Biochem Biophys Res Commun, 444 (3) (2014), pp. 296-301

57 J. Shang, Z.Y. Gao, L.Y. Zhang, et al.Over-expression of JAZF1 promotes cardiac microvascular endothelial cell proliferation and angiogenesis via activation of the Akt signaling pathway in rats with myocardial ischemia-reperfusion Cell Cycle, 18 (14) (2019), pp. 1619-1634

58 S. Talukdar, F.B. HillgartnerThe mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317 J Lipid Res, 47 (11) (2006), pp. 2451-2461

59 G. Serviddio, F. Bellanti, G. Vendemiale, et al.Oxysterols in the orchestra of liver cell metabolism Free Radic Biol Med, 75 (Suppl 1) (2014), p. S6

60 Y. Zhang, X. Fan, L. Qiu, et al.Liver X receptor α promotes milk fat synthesis in buffalo mammary epithelial cells by regulating the expression of FASN J Dairy Sci, 104 (12) (2021), pp. 12980-12993

61 Q.Y. Liu, E. Quinet, P. NambiAdipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells Mol Cell Biochem, 302 (1–2) (2007), pp. 203-213

62 D.W. Yao, J. Luo, Q.Y. He, et al.Liver X receptor α promotes the synthesis of monounsaturated fatty acids in goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase 1 in an SREBP-1-dependent manner J Dairy Sci, 99 (8) (2016), pp. 6391-6402

63 T. Nishimaki-Mogami, N. Tamehiro, Y. Sato, et al.The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines Biochem Pharmacol, 76 (8) (2008), pp. 1006-1013

64 X. Zhou, W. He, Z. Huang, et al.Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism J Biol Chem, 283 (4) (2008), pp. 2129-2138

65 M. Ayaori, E. Yakushiji, M. Ogura, et al.Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages Biochim Biophys Acta, 1821 (4) (2012), pp. 561-572

66 H.J. Wang, X.S. Zhao, H.Y. Sun, et al.Decline of ATP-binding cassette transporter G1 expressions with a liver X receptor-independent pathway in patients with type 2 diabetes J Peking Univ (Heal Sci), 46 (6) (2014), pp. 899-905

67 B. Dong, C.F. Kan, A.B. Singh, et al.High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway J Lipid Res, 54 (5) (2013), pp. 1241-1254

68 T. Inaba, M. Matsuda, M. Shimamura, et al.Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor J Biol Chem, 278 (24) (2003), pp. 21344-21351

69 K.R. Stayrook, P.M. Rogers, R.S. Savkur, et al.Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha Mol Pharmacol, 73 (2) (2008), pp. 607-612

70 Y. Yin, S. Zeng, Y. Li, et al.Macrophage Lxrα reduces atherosclerosis in Ldlr-/- mice independent of Arl7 transactivation Biochem Biophys Res Commun, 529 (3) (2020), pp. 540-547

71 M. Koh, K. Takitani, H. Miyazaki, et al.Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status J Nutr Biochem, 24 (12) (2013), pp. 2158-2167

72 S.S. Park, H. Choi, S.J. Kim, et al.FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element Mol Cell, 26 (4) (2008), pp. 409-414

73 Y. Liu, Z. Wei, X. Ma, et al.25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism J Lipid Res, 59 (3) (2018), pp. 439-451

74 T. Zhou, S. Cong, S. Sun, et al.Identification of endocrine disrupting chemicals activating SXR-mediated transactivation of CYP3A and CYP7A1 Mol Cell Endocrinol, 365 (1) (2013), pp. 36-43

75 J.F. Landrier, J. Grober, J. Demydchuk, et al.FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene FEBS Lett, 553 (3) (2003), pp. 299-303

76 O. Demeure, F. Lecerf, C. Duby, et al.Regulation of LPCAT3 by LXR Gene, 470 (1–2) (2011), pp. 7-11

77 W.F. Zhu, J.F. Zhu, L. Liang, et al.Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase Mol Med Rep, 13 (5) (2016), pp. 4487-4493

78 J. Inoue, K. Yamasaki, E. Ikeuchi, et al.Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation Mol Endocrinol, 25 (6) (2011), pp. 995-1005

79 M. Okuwaki, T. Takada, Y. Iwayanagi, et al.LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR Pharm Res (N Y), 24 (2) (2007), pp. 390-398

80 P.A. Mak, H.R. Kast-Woelbern, A.M. Anisfeld, et al.Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors J Lipid Res, 43 (12) (2002), pp. 2037-2041

81 V. Antonio, B. Janvier, A. Brouillet, et al.Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells Biochem J, 376 (Pt 2) (2003), pp. 351-360

82 B. Dong, A.B. Singh, G.L. Guo, et al.Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR Int J Mol Med, 43 (5) (2019), pp. 1927-1938

83 N. Matsushita, M.T. Hassanein, M. Martinez-Clemente, et al.Gender difference in NASH susceptibility: roles of hepatocyte Ikkβ and Sult1e1 PLoS One, 12 (8) (2017), Article e0181052

84 M. Verreault, K. Senekeo-Effenberger, J. Trottier, et al.The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice Hepatology, 44 (2) (2006), pp. 368-378

85 M. ErtenVisfatin as a promising marker of cardiometabolic risk Acta Cardiol Sin, 37 (5) (2021), pp. 464-472

86 G.F. Ming, X. Li, J.Y. Yin, et al.JAZF1 regulates visfatin expression in adipocytes via PPARα and PPARβ/δ signaling Metabolism, 63 (8) (2014), pp. 1012-1021

87 C. Janani, B.D. Ranjitha KumariPPAR gamma gene: a review Diabetes Metabol Syndr, 9 (1) (2015), pp. 46-50

88 A.N. Ilias, I.S. Ismail, H. Hamzah, et al.Rebaudioside A enhances LDL cholesterol uptake in HepG2 cells via suppression of HMGCR expression Rep Biochem Mol Biol, 10 (3) (2021), pp. 477-487

89 S. Xie, Y.F. Lee, E. Kim, et al.TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation Proc Natl Acad Sci U S A, 106 (32) (2009), pp. 13353-13358

90 S.K. Halder, M. Fink, M.R. Waterman, et al.A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14ɑ-demethylase gene (CYP51) Mol Endocrinol, 16 (8) (2002), pp. 1853-1863

91 X. He, J.L. Hu, J. Li, et al.A feedback loop in PPARγ-adenosine A2A receptor signaling inhibits inflammation and attenuates lung damages in a mouse model of LPS-induced acute lung injury Cell Signal, 25 (9) (2013), pp. 1913-1923

92 R. Madonna, D.C. RRelevance of new drug discovery to reduce NF-κB activation in cardiovascular disease Vasc Pharmacol, 57 (1) (2012), pp. 41-47

93 L. Huang, Y. Cai, Y. Luo, et al.JAZF1 suppresses papillary thyroid carcinoma cell proliferation and facilitates apoptosis via regulating TAK1/NF-κB pathways OncoTargets Ther, 12 (2019), pp. 10501-10514

94 Q. Qian, Y. Li, J. Fu, et al.Switch-associated protein 70 protects against nonalcoholic fatty liver disease through suppression of TAK1 Hepatology, 75 (6) (2022), pp. 1507-1522

95 M. He, W. Zhang, Y. Dong, et al.Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells J Exp Clin Cancer Res, 36 (2017), p. 15

96 L. Wang, Q. Zhang, Z. Wang, et al.Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-κB and TAK1 activities: cheminformatics tools RDKit applied in drug design Eur J Med Chem, 223 (2021), Article 113576

97 L. Tan, J. Zhang, Y. Wang, et al.Development of dual inhibitors targeting epidermal growth factor receptor in cancer therapy J Med Chem, 65 (7) (2022), pp. 5149-5183

98 S.K. Suthar, N. Sharma, H.B. Lee, et al.Novel dual inhibitors of nuclear factor-kappa B (NF-κB) and cyclooxygenase- 2 (COX-2):synthesis, in vitro anticancer activity and stability studies of lantadene-non steroidal anti-inflammatory drug (NSAID) conjugates Curr Top Med Chem, 14 (8) (2014), pp. 991-1004

99 J. Song, Y. Zhu, W. Zu, et al.The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth Bioorg Med Chem, 29 (2021), Article 115856

100 S. Scarneo, P. Hughes, R. Freeze, et al.Development and efficacy of an orally bioavailable selective TAK1 inhibitor for the treatment of inflammatory arthritis ACS Chem Biol, 17 (3) (2022), pp. 536-544

101 C. Wang, Y. Zhang, Y. Wu, D. XingDevelopments of CRBN-based PROTACs as potential therapeutic agents Eur J Med Chem, 225 (2021), Article 113749

102 P. Ustianowski, D. Malinowski, P. Kopytko, et al.ADCY5, CAPN10 and JAZF1 gene polymorphisms and placental expression in women with gestational diabetes Life, 11 (8) (2021), p. 806

103 Z. Ding, D. Sun, J. Han, et al.Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia Mol Metabol, 53 (2021), Article 101310

104 Q. Wang, Y. Dong, H. WangmicroRNA-19b-3p-containing extracellular vesicles derived from macrophages promote the development of atherosclerosis by targeting JAZF1 J Cell Mol Med, 26 (1) (2022), pp. 48-59

105 Q. Ding, W. Zhao, J. Long, et al.Cis-regulation of antisense non-coding RNA at the JAZF1 locus in type 2 diabetes J Gene Med, 24 (4) (2022), Article e3407

106 R. Walczak, S.B. Joseph, B.A. Laffitte, et al.Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors J Biol Chem, 279 (11) (2004), pp. 9905-9911

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⁰

New insights into the suppression of inflammation and lipid accumulation by JAZF1

DOI：10.1016/j.gendis.2022.10.029

摘要

Abstract

关键词

Keywords

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