Lysine succinylation, the metabolic bridge between cancer and immunity

Rui Shen; Hongyun Ruan; Shuye Lin; Bin Liu; Hang Song; Lu Li; Teng Ma

doi:10.1016/j.gendis.2022.10.028

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Lysine succinylation, the metabolic bridge between cancer and immunity

Review article | 更新时间：2024-02-04

- Lysine succinylation, the metabolic bridge between cancer and immunity
- Genes & Diseases Vol. 1, Issue 6, Pages: 2470-2478(2023)
- 作者机构：
  
  1. School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine,Anhui,Hefei,China,230012
  2. Cancer Research Centre, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing,China,101149
  3. Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine,Anhui,Hefei,China,230012
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.028
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Rui Shen, Hongyun Ruan, Shuye Lin, et al. Lysine succinylation, the metabolic bridge between cancer and immunity. [J]. Genes & Diseases 1(6):2470-2478(2023)
DOI：

Rui Shen, Hongyun Ruan, Shuye Lin, et al. Lysine succinylation, the metabolic bridge between cancer and immunity. [J]. Genes & Diseases 1(6):2470-2478(2023) DOI： 10.1016/j.gendis.2022.10.028.

摘要

Abstract

Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently

the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal regulation of lysine succinylation occurs in different cancers

and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies. Therefore

this review focused on the target protein lysine succinylation and its functions in cancer and immunity

in order to provide a reference for finding more potential clinical cancer targets in the future.

关键词

Keywords

ImmunityMitochondriaSIRT5Succinyl-CoASuccinylation

references

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