Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases

Qianqian Xue; Yanyan Yang; Hong Li; Xiaoxin Li; Lu Zou; Tianxiang Li; Huibo Ma; Hongzhao Qi; Jianxun Wang; Tao Yu

doi:10.1016/j.gendis.2022.10.025

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Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases

Review article | 更新时间：2024-02-04

- Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases
- Genes & Diseases Vol. 1, Issue 6, Pages: 2479-2490(2023)
- 作者机构：
  
  1. Institute for Translational Medicine, The Affiliated Hospital of Qingdao University,Shandong,Qingdao,China,266000
  2. Department of Immunology, School of Basic Medicine, Qingdao University,Shandong,Qingdao,China,266021
  3. Clinical Laboratory, Central Laboratory. The Affiliated Qingdao Hiser Hospital of Qingdao University,Shandong,Qingdao,China,266000
  4. Department of Vascular Surgery, The Affiliated Hospital of Qingdao University,Shandong,Qingdao,China,266000
  5. Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University,Shandong,Qingdao,China,266000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.025
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Qianqian Xue, Yanyan Yang, Hong Li, et al. Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases. [J]. Genes & Diseases 1(6):2479-2490(2023)
DOI：

Qianqian Xue, Yanyan Yang, Hong Li, et al. Functions and mechanisms of protein lysine butyrylation (Kbu): Therapeutic implications in human diseases. [J]. Genes & Diseases 1(6):2479-2490(2023) DOI： 10.1016/j.gendis.2022.10.025.

摘要

Abstract

Post-translational modifications (PTM) are covalent modifications of proteins or peptides caused by proteolytic cleavage or the attachment of moieties to one or more amino acids. PTMs play essential roles in biological function and regulation and have been linked with several diseases. Modifications of protein acylation (Kac)

a type of PTM

are known to induce epigenetic regulatory processes that promote various diseases. Thus

an increasing number of studies focusing on acylation modifications are being undertaken. Butyrylation (Kbu) is a new acylation process found in animals and plants. Kbu has been recently linked to the onset and progression of several diseases

such as cancer

cardiovascular diseases

diabetes

and vascular dementia. Moreover

the mode of action of certain drugs used in the treatment of lymphoma and colon cancer is based on the regulation of butyrylation levels

suggesting that butyrylation may play a therapeutic role in these diseases. In addition

butyrylation is also commonly involved in rice gene expression and thus plays an important role in the growth

development

and metabolism of rice. The tools and analytical methods that could be utilized for the prediction and detection of lysine butyrylation have also been investigated. This study reviews the potential role of histone Kbu

as well as the mechanisms underlying this process. It also summarizes various enzymes and analytical methods associated with Kbu

with the goal of providing new insights into the role of Kbu in gene regulation and diseases.

关键词

Keywords

ButyrylationGene regulationHistonePost-translational modificationTarget treatment

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