Long noncoding RNA study: Genome-wide approaches

Shuang Tao; Yarui Hou; Liting Diao; Yanxia Hu; Wanyi Xu; Shujuan Xie; Zhendong Xiao

doi:10.1016/j.gendis.2022.10.024

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Long noncoding RNA study: Genome-wide approaches

Review article | 更新时间：2024-02-04

- Long noncoding RNA study: Genome-wide approaches
- Genes & Diseases Vol. 1, Issue 6, Pages: 2491-2510(2023)
- 作者机构：
  
  1. The Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510630
  2. Institute of Vaccine, The Third Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510630
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.024
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Shuang Tao, Yarui Hou, Liting Diao, et al. Long noncoding RNA study: Genome-wide approaches. [J]. Genes & Diseases 1(6):2491-2510(2023)
DOI：

Shuang Tao, Yarui Hou, Liting Diao, et al. Long noncoding RNA study: Genome-wide approaches. [J]. Genes & Diseases 1(6):2491-2510(2023) DOI： 10.1016/j.gendis.2022.10.024.

摘要

Abstract

Long noncoding RNAs (lncRNAs) have been confirmed to play a crucial role in various biological processes across several species. Though many efforts have been devoted to the expansion of the lncRNAs landscape

much about lncRNAs is still unknown due to their great complexity. The development of high-throughput technologies and the constantly improved bioinformatic methods have resulted in a rapid expansion of lncRNA research and relevant databases. In this review

we introduced genome-wide research of lncRNAs in three parts: (i) novel lncRNA identification by high-throughput sequencing and computational pipelines; (ii) functional characterization of lncRNAs by expression atlas profiling

genome-scale screening

and the research of cancer-related lncRNAs; (iii) mechanism research by large-scale experimental technologies and computational analysis. Besides

primary experimental methods and bioinformatic pipelines related to these three parts are summarized. This review aimed to provide a comprehensive and systemic overview of lncRNA genome-wide research strategies and indicate a genome-wide lncRNA research system.

关键词

Keywords

Cancer-related lncRNAsComputational pipelinesGenome-wide studyLong noncoding RNAsTechnological approaches

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