A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Yan Lv; Xiao Ma; Yuxin Ma; Yuxin Du; Jifeng Feng

doi:10.1016/j.gendis.2022.05.020

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A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Review article | 更新时间：2024-02-04

- A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)
- Genes & Diseases Vol. 1, Issue 6, Pages: 2366-2382(2023)
- 作者机构：
  
  1. The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research,Jiangsu,Nanjing,China,210009
  2. Department of General Surgery, The Affiliated Zhongda Hospital of Southeast University,Jiangsu,Nanjing,China,210009
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.05.020
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Yan Lv, Xiao Ma, Yuxin Ma, et al. A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9). [J]. Genes & Diseases 1(6):2366-2382(2023)
DOI：

Yan Lv, Xiao Ma, Yuxin Ma, et al. A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9). [J]. Genes & Diseases 1(6):2366-2382(2023) DOI： 10.1016/j.gendis.2022.05.020.

摘要

Abstract

Over the past few decades

advances in immunological knowledge have led to the identification of novel immune checkpoints

reinvigorating cancer immunotherapy. Immunotherapy

represented by immune checkpoint inhibitors

has become the leader in the precision treatment of cancer

bringing a new dawn to the treatment of most cancer patients. Galectin-9 (LGALS9)

a member of the galectin family

is a widely expressed protein involved in immune regulation and tumor pathogenesis

and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor cell survival through its interaction with its receptor Tim-3. In the review

based on a brief description of the signaling mechanisms and immunomodulatory activities of galectin-9 and Tim-3

we summarize the targeted expression patterns of galectin-9 in a variety of malignancies and the promising mechanisms of anti-galectin-9 therapy in stimulating anti-tumor immune responses.

关键词

Keywords

Galectin-9Immune checkpoint inhibitorsImmunotherapyMonoclonal antibodyTim-3

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