The implication of pyroptosis in cancer immunology: Current advances and prospects

Wei Liu; Jinwu Peng; Muzhang Xiao; Yuan Cai; Bi Peng; Wenqin Zhang; Jianbo Li; Fanhua Kang; Qianhui Hong; Qiuju Liang; Yuanliang Yan; Zhijie Xu

doi:10.1016/j.gendis.2022.04.019

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The implication of pyroptosis in cancer immunology: Current advances and prospects

Review article | 更新时间：2024-02-04

- The implication of pyroptosis in cancer immunology: Current advances and prospects
- Genes & Diseases Vol. 1, Issue 6, Pages: 2339-2350(2023)
- 作者机构：
  
  1. Department of Pathology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  2. Department of Orthopedic Surgery, The Second Hospital University of South China,Hunan,Hengyang,China,421001
  3. Department of Pathology, Xiangya Changde Hospital,Hunan,Changde,China,415000
  4. Department of Burn and Plastic Surgery, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  5. Department of Pharmacy, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
  6. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Hunan,Changsha,China,410008
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.04.019
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Wei Liu, Jinwu Peng, Muzhang Xiao, et al. The implication of pyroptosis in cancer immunology: Current advances and prospects. [J]. Genes & Diseases 1(6):2339-2350(2023)
DOI：

Wei Liu, Jinwu Peng, Muzhang Xiao, et al. The implication of pyroptosis in cancer immunology: Current advances and prospects. [J]. Genes & Diseases 1(6):2339-2350(2023) DOI： 10.1016/j.gendis.2022.04.019.

摘要

Abstract

Pyroptosis is a regulated cell death pathway involved in numerous human diseases

especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules

like caspases

gasdermin family and inflammasomes. In addition

increasing

in vitro

and

in vivo

studies have shown the significant linkage between pyroptosis and immune regulation of cancers. Pyroptosis-associated biomarkers regulate the infiltration of tumor immune cells

such as CD4

and CD8

T cells

thus strengthening the sensitivity to therapeutic strategies. In this review

we explained the relationship between pyroptosis and cancer immunology and focused on the significance of pyroptosis in immune regulation. We also proposed the future application of pyroptosis-associated biomarkers in basic research and clinical practices to address malignant behaviors. Exploration of the underlying mechanisms and biological functions of pyroptosis is critical for immune response and cancer immunotherapy.

关键词

Keywords

Cancer immunologyImmune responseImmunotherapyPyroptosisInflammasomes

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