De novo nucleotide biosynthetic pathway and cancer
- Genes & Diseases Vol. 1, Issue 6, Pages: 2331-2338(2023)
- 作者机构：
1. Cancer Center, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430062
2. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,,.C.,Washington,D,USA,20057
- 作者简介：
- 基金信息：
DOI：10.1016/j.gendis.2022.04.018
CLC：Published：2023，
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Jie Chen, Siqi Yang, Yingge Li, et al. De novo nucleotide biosynthetic pathway and cancer. [J]. Genes & Diseases 1(6):2331-2338(2023)
Jie Chen, Siqi Yang, Yingge Li, et al. De novo nucleotide biosynthetic pathway and cancer. [J]. Genes & Diseases 1(6):2331-2338(2023) DOI： 10.1016/j.gendis.2022.04.018.
摘要
Abstract
De novo
nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation. Thus
the dysregulation of the
de novo
nucleotide biosynthetic pathway contributes to the development of many human diseases
such as cancer. It has been shown that many enzymes in this pathway are overactivated in different cancers. In this review
we summarize and update the current knowledge on the
de novo
nucleotide biosynthetic pathway
regulatory mechanisms
its role in tumorigenesis
and potential targeting opportunities.
关键词
Keywords
Biosynthetic pathwayCancerde novo synthesisMetabolismNucleotide
references
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