Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases

Chaoqun Huang; Wei Chen; Xinxia Wang

doi:10.1016/j.gendis.2022.04.014

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Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases

Review article | 更新时间：2024-02-04

- Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases
- Genes & Diseases Vol. 1, Issue 6, Pages: 2351-2365(2023)
- 作者机构：
  
  1. College of Animal Sciences, Zhejiang University,Zhejiang,Hangzhou,China,310058
  2. Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education,Zhejiang,Hangzhou,China,310058
  3. Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs,Zhejiang,Hangzhou,China,310058
  4. Key Laboratory of Animal Feed and Nutrition of Zhejiang Province,Zhejiang,Hangzhou,China,310058
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.04.014
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Chaoqun Huang, Wei Chen, Xinxia Wang. Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. [J]. Genes & Diseases 1(6):2351-2365(2023)
DOI：

Chaoqun Huang, Wei Chen, Xinxia Wang. Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. [J]. Genes & Diseases 1(6):2351-2365(2023) DOI： 10.1016/j.gendis.2022.04.014.

摘要

Abstract

Obesity has become a major health crisis in the past ∼50 years. The fat mass and obesity-associated (FTO) gene

identified by genome-wide association studies (GWAS)

was first reported to be positively associated with obesity in humans. Mice with more copies of the FTO gene were observed to be obese

while loss of the gene in mice was found to protect from obesity. Later

FTO was found to encode an m

A RNA demethylase and has a profound effect on many biological and metabolic processes. In this review

we first summarize recent studies that demonstrate the critical roles and regulatory mechanisms of FTO in obesity and metabolic disease. Second

we discuss the ongoing debates concerning the association between FTO polymorphisms and obesity. Third

since several small molecule drugs and micronutrients have been found to regulate metabolic homeostasis through controlling the expression or activity of FTO

we highlight the broad potential of targeting FTO for obesity treatment. Improving our understanding of FTO and the underlying mechanisms may provide new approaches for treating obesity and metabolic diseases.

关键词

Keywords

AdipogenesisFTOMetabolic diseasesN6-methyladenosineObesityRNA m6A modification

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