Critical involvement of circular RNAs in virus-associated cancers

Arghavan Zebardast; Tayebeh Latifi; Moein shirzad; Golnaz Goodarzi; Saeed Ebrahimi Fana; Sadra Samavarchi Tehrani; Yousef Yahyapour

doi:10.1016/j.gendis.2022.04.009

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Critical involvement of circular RNAs in virus-associated cancers

Review article | 更新时间：2024-02-04

- Critical involvement of circular RNAs in virus-associated cancers
- Genes & Diseases Vol. 1, Issue 6, Pages: 2296-2305(2023)
- 作者机构：
  
  1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
  2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran,47176
  3. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
  4. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran 141761,Iran,3151
  5. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran,47176
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.04.009
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Arghavan Zebardast, Tayebeh Latifi, Moein shirzad, et al. Critical involvement of circular RNAs in virus-associated cancers. [J]. Genes & Diseases 1(6):2296-2305(2023)
DOI：

Arghavan Zebardast, Tayebeh Latifi, Moein shirzad, et al. Critical involvement of circular RNAs in virus-associated cancers. [J]. Genes & Diseases 1(6):2296-2305(2023) DOI： 10.1016/j.gendis.2022.04.009.

摘要

Abstract

Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host's infected cells. Seven viruses (e.g.

human papillomavirus (HPV)

Epstein–Barr virus (EBV)

Kaposi's sarcoma herpesvirus (KSHV)

Hepatitis B virus (HBV)

Hepatitis C virus (HCV)

Human T-lymphotropic virus (HTLV)

and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently

growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs)

due to the absence of 5′ and 3′ ends

have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs

as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore

understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence

in this review

we will focus on emerging roles of virus-encoded circRNAs in multiple cancers

including cervical cancer

gastric cancer

Merkel cell carcinoma

nasopharyngeal carcinoma

Kaposi cancer

and liver cancer.

关键词

Keywords

CancerCircular RNANeoplasmsOncogenesViruses

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