The crucial roles of m<sup>6</sup>A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies

Cong Huang; Kaoyuan Zhang; Yang Guo; Changbing Shen; Xiaoming Liu; Haiyan Huang; Xia Dou; Bo Yu

doi:10.1016/j.gendis.2022.03.006

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The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies

Review article | 更新时间：2024-02-04

- The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies
- Genes & Diseases Vol. 1, Issue 6, Pages: 2320-2330(2023)
- 作者机构：
  
  1. Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Guangdong,Shenzhen,China,518036
  2. Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital,Guangdong,Shenzhen,China,518036
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.03.006
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
扫描看全文
Cong Huang, Kaoyuan Zhang, Yang Guo, et al. The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies. [J]. Genes & Diseases 1(6):2320-2330(2023)
DOI：

Cong Huang, Kaoyuan Zhang, Yang Guo, et al. The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies. [J]. Genes & Diseases 1(6):2320-2330(2023) DOI： 10.1016/j.gendis.2022.03.006.

摘要

Abstract

N6-methyladenosine (m

A) is the most abundant internal modification on RNA. It is a dynamical and reversible process

which is regulated by m

A methyltransferase and m

A demethylase. The m

A modified RNA can be specifically recognized by the m

A reader

leading to RNA splicing

maturation

degradation or translation. The abnormality of m

A RNA modification is closely related to a variety of biological processes

especially the occurrence and development of tumors. Recent studies have shown that m

A RNA modification is involved in the pathogenesis of skin cancers. However

the precise molecular mechanisms of m

A-mediated cutaneous tumorigenesis have not been fully elucidated. Therefore

this review will summarize the biological characteristics of m

A modification

its regulatory role and mechanism in skin cancers

and the recent research progress of m

A-related molecular drugs

aiming to provide new ideas for clinical diagnosis and targeted therapy of cutaneous cancers.

关键词

Keywords

Cutaneous squamous cell carcinomaCutaneous melanomam6A modificationm6A-related drugsTarget therapy

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Related Author

Jun Li

Lijiao Sun

Xin Chen

Sai Zhu

Jianan Wang

Shaoxi Diao

Jinyu Liu

Jinjin Xu

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Department of Oncology, The First Affiliated Hospital of Anhui Medical University

Institute for Liver Diseases of Anhui Medical University, ILD-AMU, Anhui Medical University

The Key Laboratory of Anti-inflammatory and Immune Medicines, Anhui Medical University, Ministry of Education

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The crucial roles of m6A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies

DOI：10.1016/j.gendis.2022.03.006

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Abstract

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references

The crucial roles of m⁶A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies