Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury

Yu Yang; Xianhe Lin

doi:10.1016/j.gendis.2022.02.012

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Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury

Review article | 更新时间：2024-02-04

- Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury
- Genes & Diseases Vol. 1, Issue 6, Pages: 2285-2295(2023)
- 作者机构：
  
  1. Cardiology Department, The First Affiliated Hospital of Anhui Medical University,Anhui,Hefei,China,230022
  2. Anhui Medical University,Anhui,Hefei,China,230032
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.02.012
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Yu Yang, Xianhe Lin. Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury. [J]. Genes & Diseases 1(6):2285-2295(2023)
DOI：

Yu Yang, Xianhe Lin. Potential relationship between autophagy and ferroptosis in myocardial ischemia/reperfusion injury. [J]. Genes & Diseases 1(6):2285-2295(2023) DOI： 10.1016/j.gendis.2022.02.012.

摘要

Abstract

utophagy is an evolutionarily conserved process involved in the degradation of long-lived proteins and excessive or dysfunctional organelles. As a pivotal cellular response

autophagy has been extensively studied and is known to be involved in various diseases. Ferroptosis is a recently discovered form of regulated cell death characterized by iron overload

leading to the accumulation of lethal levels of lipid hydroperoxides. Recently

an increasing number of studies have revealed a link between autophagy and ferroptosis. Myocardial ischemia/reperfusion injury (MIRI) is an urgent dilemma after myocardial infarction recanalization

which is regulated by several cell death pathways

including autophagy and ferroptosis. However

the potential relationship between autophagy and ferroptosis in MIRI remains unexplored. In this study

we briefly review the mechanisms of autophagy and ferroptosis

including their roles in MIRI. Moreover

we provide an overview of the potential crosstalk in MIRI. Clarifying the relationship between different cell death pathways may provide new ideas for the treatment of MIRI in the future.

关键词

Keywords

AutophagyFerroptosisIron overloadMyocardial ischemia/reperfusion injuryRelationship

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