Interest in learning can not only stimulate students' enthusiasm for learning

but also directly affect the quality of higher education. In this paper

the questionnaire of the related factors of college students' interest was designed to carry out micro-system engineering research. The factors as-sociated with college students' interest in learning and their complex relationships were investigated by using methods of systems science and systems engineering. The results shows that the students who can actively participate in after-school learning discussions

feel good in lectures and have clear learning objectives

are interested in learning. And at the same time

the teacher's influence and his active guidance in classroom teaching will raise students' interest in learning. This study provides a more comprehensive basis and clues to improve students' interest in learning and education reform.