Objective　To develop the interacting learning mode in simulative situation on sex and health courses for college students and evaluate the effect of it. Methods　The core curriculum for general education of sex and health was open to all the students in Shanghai Jiao Tong University from Feb. 2010 to Jun. 2011. The courses imported simulative-situation-learning method. At the end of the semester， the feedback and the suggestion of the students were collected and sorted. Results　All groups from the course involved the simulative situation seriously， which included homosexuality of college students， un-desired pregnancy and contraception knowledge， etc. According to the feedback of the courses

most of the students acceptted this kind of teaching method. Conclusion　Interacting learning in simulative situation can obviously increase the interest and enthusiasm of students. Meanwhile， the new courses not only im-prove students' understanding of knowledge， but also improve their communication skills and team work ability.