Objective　To investigate the teaching effects of Sandwich teaching mode applied in clinical oncology teaching. Methods　Totally 72 clinical medicine undergraduates were divided into two groups randomly： Sandwich teaching group and traditional teaching group. Sandwich teaching mode was introduced to Sandwich teaching group while traditional teaching mode was carried out in traditional teaching group. Questionnaires and test paper were analyzed between the two groups and two teaching modes were evaluated. Examination results were statistically analyzed by t test. Results　According to the questionnaires， more than 80 percent of the students thought that the initiative and enthusiasm were fully mobilized by the Sandwich teaching mode. Studying efficiency was improved significantly and skills of independent thinking， comprehensive analysis and problem-solving were trained， meanwhile， Sandwich teaching mode can improve the ability of expression and communication. Test score of students in Sand-wich teaching group was higher than those in traditional teaching group（P<0.05）. Conclusions　Sand-wich teaching mode has obvious advantages in improving teaching quality of clinical oncology and it may help to cultivate high quality oncology specialists.