Objective　To analyze the factors that influence the learning effectiveness of students in higher vocational medical school and to explore the ways to improve the teaching effect of higher medi-cal vocational education. Methods　Self-designed questionnaire survey was conducted to investigate the basic condition， study status， teaching satisfaction degree and socre influencing factors of 639 students before internships. Teaching efficacy was assessed by scores（taking full score 100 as the standard， ≥85 are the first class， ≤70 are the second class and the rest are the third class ）. SPSS 14.0 was employed to do statically analysis and an orderly regression analysis was made by taking the factors affecting student learning outcomes as independent variable and the level of learning outcomes as dependent variable. Results　There were statically differences in learning efficacy between nurse group and medical student group（Z=-4.817，P=0.000）. Students' interests in discipline， family rearing patterns， secondary educa-tion means， whether doing preview and study style satisfaction were factors that influence the learning effectiveness. Conclusions　Strengthening ideological education and learning atmosphere improvement as well as encouraging students to adopt appropriate learning methods can help students improve their learn-ing effectiveness.