Objective　To explore the clinical nursing path teaching method application in children with mycoplasma pneumonia and its effect. Methods　93 higher vocational nursing students of two classes of Grade 2011 were chosen as the subjects， one class as the experimental group（46）， and the other class as the control group（47）. The traditional teaching method was used in the control group， while method of clinical nursing path was used in the experimental group. Two groups of nurs ing students were given closed book exams and questionnaires to evaluate teaching effectiveness of the two groups. SPSS 13.0 was used for statistical analysis， count data using ?字2 test， measurement data using t test， test level ?琢=0.05. Results　The experimental group students' test scores were significantly higher than the control group（85.26±3.57）vs. （76.39±4.16）， and the difference was statistically significant P=0.02. The survey showed that there were more students in the experimental group than in the control group who made a positive comment on the questionnaire's role in helping improve students' learning autonomy， their critical thinking ability， and promote their grasp of the content of the disease. Conclusion　Clinical nursing path teaching method as a new kind of teaching method， can improve the teaching effect.