THE PHARMACOEINETICS AND ACUTE TOXICITY OF MICRONIZED NITRODIPHENYLAMINOISOTHIOCYANATE(7505)AQUEOUS SUSPENSION FOR INTRAVENOUS INJECTION

Department of Pharmacology:Chen Gurong Tu Zhiguang Quan Yuzhu

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THE PHARMACOEINETICS AND ACUTE TOXICITY OF MICRONIZED NITRODIPHENYLAMINOISOTHIOCYANATE(7505)AQUEOUS SUSPENSION FOR INTRAVENOUS INJECTION

更新时间：2024-01-17

- THE PHARMACOEINETICS AND ACUTE TOXICITY OF MICRONIZED NITRODIPHENYLAMINOISOTHIOCYANATE(7505)AQUEOUS SUSPENSION FOR INTRAVENOUS INJECTION
- Journal of Chongqing Medical University Issue 3, Pages: 158-160(1984)
- 作者机构：
  
  1. 四川省中药研究所
  2. 重庆医学院药理教研室
  3. 重庆医学院药理教研室进修员
  4. 四川省中药研究所重庆医学院药理教研室重庆医学院药理教研室进修员
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1984，
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[1]陈古荣,涂植光,全钰珠.硝酸氰胺静注混悬剂的药代动力学和急性毒性[J].重庆医学院学报,1984(03):158-160.

Department of Pharmacology:Chen Gurong Tu Zhiguang Quan Yuzhu. THE PHARMACOEINETICS AND ACUTE TOXICITY OF MICRONIZED NITRODIPHENYLAMINOISOTHIOCYANATE(7505)AQUEOUS SUSPENSION FOR INTRAVENOUS INJECTION. [J]. Journal of Chongqing Medical University (3):158-160(1984)
[1]陈古荣,涂植光,全钰珠.硝酸氰胺静注混悬剂的药代动力学和急性毒性[J].重庆医学院学报,1984(03):158-160. DOI：

Department of Pharmacology:Chen Gurong Tu Zhiguang Quan Yuzhu. THE PHARMACOEINETICS AND ACUTE TOXICITY OF MICRONIZED NITRODIPHENYLAMINOISOTHIOCYANATE(7505)AQUEOUS SUSPENSION FOR INTRAVENOUS INJECTION. [J]. Journal of Chongqing Medical University (3):158-160(1984) DOI：

摘要

<正> 硝硫氰胺（Nithiocyamine

“7505”）

为一新型抗血吸虫药

由于本品难溶于水

故药代动力学的研究

受到一定限制。最近

上海医药工业研究院试制出供家畜静脉注射用的硝硫氰胺混悬剂。本文乃采用该制剂给健康家兔进行静脉注射

观察硝硫氰

Abstract

The pharmacokinetics of Nitrodiphenylaminoisothiocyanate（7505）in the healthy rabbits was studied.The micronized 7505 aqueous suspension was given to rabbits by intravenous injection.The plasma C-T curve indicated that the data fitted a two-compartment open model. The pharmacokinetic parameters are:t1/2α

1.253hr;t1/2β

13.509hr;K

0.258hr

-1

0.214hr

-1

0.133hr

-1

3.687 1/kg;V

4.441 1/kg;V

9.520 1/kg;Q

0.488 1/kg/ hr;AUC

0-16

11.091 mg.hr/1. The mice acute LD

of micronized 7505 in aqueous suspension by intravenous or intraperitoneal injection was 169.99±13.77mg/kg（P=0.95）or 180.50±21.13mg/kg（P=0.95）respectively.It seems that the formulated dosage form given intravenusly is not more toxic significantly than given intraperitoneally.

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