HEPATIC COMA AND“TYROSINE-LIKE”TOXIC COMPOUNDS

Department of Biochemistry wang Zhen Tai Zhang Ya Li Qian Huang Meng Yang Hui

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HEPATIC COMA AND“TYROSINE-LIKE”TOXIC COMPOUNDS

更新时间：2024-01-17

- HEPATIC COMA AND“TYROSINE-LIKE”TOXIC COMPOUNDS
- Journal of Chongqing Medical University Issue 4, Pages: 243-245(1984)
- 作者机构：
  
  重庆医学院生化教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1984，
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[1]王征泰,张亚,李倩,黄萌,杨惠.肝性昏迷与“酪氨酸样”毒性化合物[J].重庆医学院学报,1984(04):243-245.

Department of Biochemistry wang Zhen Tai Zhang Ya Li Qian Huang Meng Yang Hui. HEPATIC COMA AND“TYROSINE-LIKE”TOXIC COMPOUNDS. [J]. Journal of Chongqing Medical University (4):243-245(1984)
[1]王征泰,张亚,李倩,黄萌,杨惠.肝性昏迷与“酪氨酸样”毒性化合物[J].重庆医学院学报,1984(04):243-245. DOI：

Department of Biochemistry wang Zhen Tai Zhang Ya Li Qian Huang Meng Yang Hui. HEPATIC COMA AND“TYROSINE-LIKE”TOXIC COMPOUNDS. [J]. Journal of Chongqing Medical University (4):243-245(1984) DOI：

摘要

<正> 近年来对肝性昏迷的病因与发病机制

已有较深入的研究

并提出多种假说。先后报导的“毒性物质”或与之有关的化合物有氨、芳香族氨基酸、短链脂酸、硫醇、γ—氨基丁酸及中分子化合物等。但由于实验的设计、方法

动物模型或所选的病例各不相同

所得结果有很大差异

难以比较。至今尚无较公认的结论。1972年以来

有关人工肝辅助装置的研

Abstract

Mice with hepatic coma were obtained by i.p.injection of d-galactosmine.The “tyrbsine- like” compounds in the serum and brain Of the coma mice were determined by the combination of ion-exchange resin separation and Wong’s spectroflurophotometric method In hepatic coma mice

we could not demonstrate the existence of “tyrosine-like” toxic substances supposed by P. Bloch et al.

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