Clinical  significance  and  immunohistochemical  assays  of   P-glycoprotein  of preoperative  chemotherapy  for  Wilms’  tumor

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Clinical significance and immunohistochemical assays of P-glycoprotein of preoperative chemotherapy for Wilms’ tumor

更新时间：2024-01-17

- Clinical significance and immunohistochemical assays of P-glycoprotein of preoperative chemotherapy for Wilms’ tumor
- Journal of Chongqing Medical University Issue 1, Pages: 34-36(2001)
- 作者机构：
  
  重庆医科大学儿科学院外科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.11
- Published：2001，
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[1]魏光辉,金先庆,李旭良,林涛,何大维.肾母细胞瘤术前化疗前后P-糖蛋白表达的变化及临床意义[J].重庆医科大学学报,2001(01):34-36.

Clinical significance and immunohistochemical assays of P-glycoprotein of preoperative chemotherapy for Wilms’ tumor. [J]. Journal of Chongqing Medical University (1):34-36(2001)
[1]魏光辉,金先庆,李旭良,林涛,何大维.肾母细胞瘤术前化疗前后P-糖蛋白表达的变化及临床意义[J].重庆医科大学学报,2001(01):34-36. DOI：

Clinical significance and immunohistochemical assays of P-glycoprotein of preoperative chemotherapy for Wilms’ tumor. [J]. Journal of Chongqing Medical University (1):34-36(2001) DOI：

摘要

目的：探讨肾母细胞瘤术前化疗耐药性的生物学特性及与疗效相关性。方法：对18例未术前化疗和经不同疗程术前化疗病理档案，以JSD-单克隆抗体对肾母细胞瘤组织多药耐药蛋白（P-glycoprotein

P-gp）进行免疫组织化学，检测P-gp在术前化疗不同疗程的表达

确定其耐药性；同时对15例资料记录完整、术前化疗>5周的小儿肾母细胞瘤，通过B超随访测量术前化疗不同疗程肿瘤大小

了解其疗效及与耐药性的相关性。结果：术前化疗后的肿瘤细胞P-gp表达比未经术前化疗的肿瘤细胞强，而术前化疗疗程越长，肿瘤细胞P-gp表达越强，疗效降低。结论：术前化疗4周后疗效降低与瘤组织对化疗药物耐药性明显增强有关，免疫组织化学检测P-gp可为制定或更改肾母细胞瘤术前化疗方案及术后化疗方案提供有用的依据。

Abstract

Objective: To explore the decrease of the efficacy of preoperative chemotherapy decreases with the period of chemotherapy due to multidrug resistance. Methods: We analyzed 18 cases with or without preoperative chemotherapy. Monoclonal antibody was used to detect the expression of P-glycoprotein (P-gp) in Wilms’ tumor. Fifteen Wilms’ tumor cases with complete clinical records and more than five weeks preoperative chemotherapy were followed up by ultrosonography to identify the relationship between the volume of tumor and the period of chemotherapy and multidrug resistance. Results: It was suggested that the expression of multidrug resistance increases after preoperative chemotherapy. The longer the preoperative chemotherapy

the stronger the expression of multidrug resistance. Conclusion: We have found that decrease of efficacy of chemotherapy after four weeks preoperative chemotherapy is due to the increase of multidrug resistance. We recommend that determination of P-gp using immunohistochemical assay can be served as a basis to formulate preoperative and/or postoperative chemotherapy treatment program.

关键词

肾母细胞瘤术前化疗多药耐药蛋白

Keywords

Wilms’ tumorPreoperative chemotherapyP-glycoprotein

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