Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis

您当前的位置：

首页 >

文章列表页 >

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis

更新时间：2024-01-17

- Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis
- Journal of Chongqing Medical University Issue 4, Pages: 383-385(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科,重庆医科大学临床学院妇产科,四川省妇幼保健院,重庆市第四人民医院,重庆医科大学第二临床学院重庆　400016,重庆　400016,成都,610041
  2. ,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.71
- Published：2002，
扫描看全文
[1]令狐华,徐小蓉,庄琳,周晓,赵建武.子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达[J].重庆医科大学学报,2002(04):383-385.

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis. [J]. Journal of Chongqing Medical University (4):383-385(2002)
[1]令狐华,徐小蓉,庄琳,周晓,赵建武.子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达[J].重庆医科大学学报,2002(04):383-385. DOI：

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis. [J]. Journal of Chongqing Medical University (4):383-385(2002) DOI：

摘要

目的：检测子宫内膜异位症（EM）患者在位及异位内膜中Fas，FasL蛋白的表达，探讨其在子宫内膜异位症免疫发病机制中的作用。方法：采用免疫组织化学（SP）法分别测定了EM患者在位和异位内膜及正常对照子宫内膜中Fas，FasL蛋白的表达。结果：1、EM患者在位内膜及正常对照子宫内膜中Fas及FasL的表达均呈周期性改变，增生期呈低水平表达，分泌期表达增高，两组间同期别比较增生期无显著差异，分泌期EM患者在位内膜的Fas及FasL表达均低于正常对照组；2、异位子宫内膜中的Fas及FasL的表达都呈现低水平或不表达。结论：子宫内膜异位种植可能与Fas及FasL的表达障碍有关。

Abstract

Objective: To investigate the effect of Fas/ Fas ligand expression on the pathogenesis of endometriosis( EM ). Methods: Immunohistochemistry was used to assess the expression of Fas and Fas ligand (FasL) in ectopic and eutopic endometrium from patients with EM and those from controls. Results: Eutopic endometrium showed a cyclic change in correlation with the menstrual cycle both in patients with EM and in controls

with Fas/FasL staining found to be increased in secretory phase compared with those in proliferative phase. Although no difference was found between patients with EM and control in their Fas/FasL expression in proliferative phase

there was a decreased level of Fas/ FasL expression in secretory endometria of patients with EM . Notably

expression of the two parameters in ectopic endometrium was observed to be quite low. Conclusion:The low level of Fas and FasL expression in secretory eutopic endometrium and in ectopic endometrium may participate in the ectopic transplantation of endometriosis.

关键词

子宫内膜异位子宫内膜FasFas Liand

Keywords

EndometriosisendometriumFasFas ligand

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation

Nme2 participates in decidualization in mice stromal cells

Vary rules and potential role of ApoA Ⅳ in different stages of mice and females during pregnancy

CHROMOSOME ANALYSIS OF ENDOMETRIUM BEFORE AND AFTER CLOMIPHENE THERAPY

Establishment of endometrial stromal cellls model

Related Author

Sun Congcong

Wang Jia

Ming Xue

Gao Yanghong

Zhang Yingfeng

Chen Huaimei

Zhang Xue

Zhang Shuang

Related Institution

Department of Obstetrics and Gynecology,University-Town Hospital of Chongqing Medical University

Department of Comprehensive Herbal Medicine,Traditional Chinese Medicine School,Chongqing Medical University

Laboratory of the Reproductive Biology, School of Public Health and Management,Chongqing Medical University

Obstetrics and Gynecology Laboratory,The First Affiliated Hospital of Chongqing Medical University

Laboratory of Reproductive Biology,College of Public Health and Management,Chongqing Medical University

⁰