Study on efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction

ZHANG Weili; et al

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Study on efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction

更新时间：2024-01-17

- Study on efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction
- Journal of Chongqing Medical University Issue 2, Pages: 187-189(2002)
- 作者机构：
  
  1. 重庆医科大学第二临床学院泌尿外科
  2. 解放军总医院医学统计教研室,重庆,400010
  3. ,北京,100039
- 作者简介：
- 基金信息：
- DOI：
  CLC： R698.1
- Published：2002，
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[1]张唯力,胡自力,姚晨.枸橼酸西地那非片治疗男性阴茎勃起功能障碍有效性及安全性的临床研究[J].重庆医科大学学报,2002(02):187-189.

ZHANG Weili, et al. Study on efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction. [J]. Journal of Chongqing Medical University (2):187-189(2002)
[1]张唯力,胡自力,姚晨.枸橼酸西地那非片治疗男性阴茎勃起功能障碍有效性及安全性的临床研究[J].重庆医科大学学报,2002(02):187-189. DOI：

ZHANG Weili, et al. Study on efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction. [J]. Journal of Chongqing Medical University (2):187-189(2002) DOI：

摘要

目的:评估国产枸橼酸西地那非片用于治疗男性勃起功能障碍的有效性及安全性。方法:采用随机双盲、安慰剂平行对照、剂量可调的持续8周的临床研究

例受试者参加本研究。72结果:临床有效率西地那非组为

安慰剂组为88.89%;西地那非组有的受试者认为研究药物改善了其勃起功能

显著高于安慰剂组的;西地那非组的所有受22.22%85.71%20.00%试者的性交成功率为

显著高于安慰剂组);发生不良事件中西地那非组较安慰剂组高

但均为轻度和短暂82.01%(20.31%的。结论:国产枸橼酸西地那非片为一种安全、有效的治疗男性勃起功能障碍的药物。

Abstract

Objective: To evaluate the efficacy and safety of sildenafil on men with erectile dysfunction. Methods:This study was a double-blind

randomizes

placebo-controlled

flexible dose study of sildenafil citrate oral tablets taken 8 weeks. A total of 72 subjects were screened and randomized. Results: Clinical effective rate was of 88.89% on sildenafil vs 22.22% on placebo. The global assessment question revealed that treatment had improved their erection in 85.71% on sildenafil vs 20.00% on placebo. The proportion of successful attempts at sexual intercourse was 82.01% on sildenafil vs 20.31% on placebo. The incidence of adverse events was higher for sildenafil than for placebo

but sildenafil was well tolerated. Conclusion: Oral sildenafil is safe and effective for male erectile dysfunction.

关键词

枸橼酸西地那非勃起功能障碍有效性安全性

Keywords

Sildenafil citrateerectile dysfunctionefficacysafety

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