Objective: To research neostigmine whether it has analgesic effect. At the same time

to value the clinical efficacy and safety of epidural analgesia using neostigmine. This can offer experimental and theoretical data for epidural analgesia using neostigmine on postoperative patients. Methods: Thirty-three patients were randomly and double-blind entered into four groups. Give each subject the analgesic liquid as required. Record vital signs

VAS grade

side effects. Results: No severe side effects are found in each patient. The VAS grade 24h after operation: Group D>Group C>Group A>Group B. Between Group A

Group B and Group C

Group D

there was significant difference. Conclusion: Epidural neostigmine can provide analgesia in some degree. Neostigmine 0.5mg and 1mg produce better analgesia effect than 1.5mg and normal saline

besides

the incidence of side effect was lower. All above indicate that neostigmine can be used with other analgesics for more comfortable analgesia with less side effect.