Experiment model of chronic myocardial infarction in rats

LIU Yuansheng; et al

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Experiment model of chronic myocardial infarction in rats

更新时间：2024-01-17

- Experiment model of chronic myocardial infarction in rats
- Journal of Chongqing Medical University Issue 2, Pages: 153-155(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学临床学院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332
- Published：2002，
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[1]刘元生,陈运贞.慢性心肌梗塞大鼠实验模型[J].重庆医科大学学报,2002(02):153-155.

LIU Yuansheng, et al. Experiment model of chronic myocardial infarction in rats. [J]. Journal of Chongqing Medical University (2):153-155(2002)
[1]刘元生,陈运贞.慢性心肌梗塞大鼠实验模型[J].重庆医科大学学报,2002(02):153-155. DOI：

LIU Yuansheng, et al. Experiment model of chronic myocardial infarction in rats. [J]. Journal of Chongqing Medical University (2):153-155(2002) DOI：

摘要

目的:建立慢性心肌梗塞大鼠实验模型。方法:大鼠用氯胺酮、戊巴比妥钠、阿托品和利多卡因复合麻醉

Wistar气管切开插管

经左胸第、肋间钝性分离开胸

结扎左冠状动脉前降支。 34结果:本法术后内大鼠死亡率仅为;存72h6.67%活周以上大鼠可达。378.1%结论:本技术操作简单、创伤轻、成功率高、结果可靠。

Abstract

Objective: To make animal model of chronic myocardial infarction in rats. Methods: Wistar rats were anaesthetized with ketamine

sodium phenobarbital

atropine and lidocaine. Tracheotomy intubation and left anterior thoracotomy through 3

4 intercostal region were performed. Left anterior`descending coronary artery was ligated. Results: Rat mortality was 6.67% in 72 hours after operation. The survival rate was 78.1% beyond 3 weeks. Conclusion: This showed that the operation procedure was easy to perform with slight damage and high survival rate.

关键词

心肌梗塞大鼠动物模型

Keywords

Myocardial infarctionratsanimal model

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Related Institution

Lanzhou University，School of Basic Medical Sciences

Gansu Provincial Hospital，Department of Cardiology

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