The relationship between urinary type Ⅳ collagen and diabetic nephropathy in type 2 diabetes mellitus patients

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The relationship between urinary type Ⅳ collagen and diabetic nephropathy in type 2 diabetes mellitus patients

更新时间：2024-01-17

- The relationship between urinary type Ⅳ collagen and diabetic nephropathy in type 2 diabetes mellitus patients
- Journal of Chongqing Medical University Issue 1, Pages: 23-24(2001)
- 作者机构：
  
  重庆医科大学第二临床学院内分泌科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2001，
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[1]胡怀东,王玉君,庞久高.2型糖尿病患者尿Ⅳ型胶原与糖尿病肾病关系的研究[J].重庆医科大学学报,2001(01):23-24+28.

The relationship between urinary type Ⅳ collagen and diabetic nephropathy in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (1):23-24(2001)
[1]胡怀东,王玉君,庞久高.2型糖尿病患者尿Ⅳ型胶原与糖尿病肾病关系的研究[J].重庆医科大学学报,2001(01):23-24+28. DOI：

The relationship between urinary type Ⅳ collagen and diabetic nephropathy in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (1):23-24(2001) DOI：

摘要

目的：研究2型糖尿病患者尿Ⅳ型胶原（CⅣ）的变化及其对糖尿病肾病（DN）的诊断意义。方法：用放免法测定了72例2型糖尿病（DM）患者及30例正常人尿CⅣ、UAE、α1-微球蛋白（α1-MG）水平。结果：72例患者尿CⅣ水平明显高于对照组；在正常白蛋白尿期2型DM病人尿CⅣ较对照组已明显升高（Ｐ<0.05），各组间尿CⅣ水平差异显著，随24h尿白蛋白排泄量（UAE）的增加而递增。尿CⅣ与UAE、α1-MG 、收缩压（sBP）、病程、糖化血红蛋白（HbA1c）呈正相关。结论：提示尿CⅣ随DN的严重程度而明显增高，可用来早期诊断DN，监测DN的发生发展。

Abstract

Objective: To investigate the change of urinary type Ⅳ collagen(CⅣ)level in type 2 diabetes mellitus patients. Methods: The level of urinary CⅣ

UAE and α1-MG was measured by radioimmunoassay (RIA) in 72 diabetic patients and 30 controls. Results: Urinary CⅣ in 72 diabetic patients was significantly increased. As compared with controls

urinary CⅣ was markedly higher in type 2 diabetic patients with normal albuminuria. Urinary CⅣ level was different in three groups

and increased with UAE.There was positive correlation between urinary CⅣ level and UAE

α1-MG

duration

sBP

HbA1c. Conclusion: The present findings suggest that measurement of urinary CⅣ is useful for the detection of early diabetic nephropathy.

关键词

2型糖尿病Ⅳ型胶原糖尿病肾病

Keywords

type 2 diabetes mellitusDiabetic nephropathyType Ⅳ collagen

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