Objective: 、To study the expression and clinical significance of VEGFCK20 in transitional cell carcinoma (TCC) of bladder. Methods: S-P immunohistochemical method was used to evaluate the expression of 、VEGF CK20 in 30 TCC of bladder and 13 specimens of normal bladder mucosa. Results: The result showed 、()、()the positive rate of VEGFCK20 in TCC of bladder was 83.3%25/3063.3%19/30 respectively and ()、()the positive rate in normal bladder mucosa was 6.7%2/300%0/30respectively. Statistically positive 、expression of VEGFCK20 was correlated with histological classification and grade. VEGF expression was significantly correlated to the expression of CK20

overexpression of VEGF and CK20 in metastasis of regional lymph node. Conclusion: 、、 VEGFCK20 overexpression in TCC of bladder was related to the proliferationhistodifferentiation and metastasis of cancer cells

so it could be used as a useful marker of supplementarydiagnosis

evaluation of malignant degrees and prognosis for the patients.