Effect of domestic glutathione treatment in the alcoholic liver disease

您当前的位置：

首页 >

文章列表页 >

Effect of domestic glutathione treatment in the alcoholic liver disease

更新时间：2024-01-17

- Effect of domestic glutathione treatment in the alcoholic liver disease
- Journal of Chongqing Medical University Issue 4, Pages: 458-460(2002)
- 作者机构：
  
  1. 重庆医科大学肝炎研究所,重庆医科大学肝炎研究所,重庆医科大学肝炎研究所,昆明医学院第一医院传染科,昆明医学院第二医院消化科,昆明医学院第一医院传染科,昆明医学院第二医院消化科,重庆医科大学肝炎研究所重庆　400010,重庆　400010,重庆　400010,昆明,650000
  2. 650000,昆明　650000,昆明　650000,重庆,昆明,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R575.05
- Published：2002，
扫描看全文
[1]赵有蓉,张定凤,曾维群,唐宝璋,李兆福,游晶,吕琳,陈压西.国产还原型谷胱甘肽治疗酒精性肝病临床疗效的研究[J].重庆医科大学学报,2002(04):458-460.

Effect of domestic glutathione treatment in the alcoholic liver disease. [J]. Journal of Chongqing Medical University (4):458-460(2002)
[1]赵有蓉,张定凤,曾维群,唐宝璋,李兆福,游晶,吕琳,陈压西.国产还原型谷胱甘肽治疗酒精性肝病临床疗效的研究[J].重庆医科大学学报,2002(04):458-460. DOI：

Effect of domestic glutathione treatment in the alcoholic liver disease. [J]. Journal of Chongqing Medical University (4):458-460(2002) DOI：

摘要

目的：通过多中心，随机、双盲对照的临床试验，研究国产四类新药注射用还原型谷胱甘肽（GSH）治疗酒精性肝病的疗效及安全性。方法：选择酒精性肝病120例，随机双盲分为治疗组60例，采用GSH 1200mg加入10%GS 250ml 静脉滴注，一日一次，疗程30天。对照组60例，以意大利Laboratorio Farmaceutico C.T.s.r.l 生产的还原型谷胱甘肽（古拉定GLT）为对照药，用药剂量、途径、疗程同GSH。观察指标肝功能、血脂、消化道症状和体征。结果：治后治疗组、对照组血清ALT、AST复常率分别为75.0%（45/60）、75.44%（43/57）和76.67%（46/60）、76.27%（45/59）（ P均>0.05）。治后1月随访GSH治疗组显效率65%、有效率10%，对照组显效68。33%、有效10%，两者分别比较均无显著性差异（P均>0.05）。治疗后两组临床症状均有改善，黄疸消退。个别病例皮肤搔痒，未见明显不良反应。结论：国产注射用GSH治疗酒精性肝病，对肝功能恢复及改善临床症状有较好的治疗作用，安全性好。

Abstract

Objective: To evaluate the effect and safety of domestic glutathione (GSH ) on the lowering of serum ALT

AST levels in alcoholic liver disease (ALD) by multi-center

randomized

double blind and controlled trial. Methods: 120 patients with ALD were enrolled and randomized into GSH and GLT control groups. 60 patients received continuous infusion of GSH 1200mg daily for 30d and 60 patients received GLT with the same dose

route and course as GSH .The efficacy and safety were evaluated with clinical

biochemical (ALT

AST

GGT

TG and ApoAI ) parameters. Results: After 4 week treatment serum ALT AST normalization rate showed no significant difference in the two groups （75.0 %vs75.44%） and（76.67% vs 76.27 %）(P>0.05) . After 8 week treatment

there was no marked efficacy and efficacy difference between GSH and GLT groups ( 65.0% vs68.33% and 10.0% vs10.0.%

P>0.05)

clinical signs were improved at different degree in both groups. There was few severe drug-related adverse event. Conclusion: Sound efficacy in the improvement of clinical signs

and hepatic functions could be obtained from treatment with domestic GSH on the ALD accompanied with good safety.

关键词

酒精性肝病还原型谷胱甘肽疗效

Keywords

Alcoholic liver diseaseglutathioneEffect

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of glutathione on chronic liver injury in rat

Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people

Clinical value of ribs removal for treating middle-late stage primary liver cancer using HIFU plus TACE

Clinical effect of montelukast combined salmeterol and fluticasone propionate dry powder in children with moderate to severe asthma

Stapled hemorrhoid treatment of mucous membrane of circumcision experience of 75 cases of hemorrhoids translated text

Related Author

郭树华

et al

SHI Xiaofeng

袁伟建

et el

LENG Ai-min

et al

冉立峰

Related Institution

Institute for Viral Hepatitis, Chongqing Medical University

重庆医科大学病毒性肝炎研究所

Department of Gastroenterology,Xiangya Hospital,Central South University

Clinical Center for Tumor Therapy,the Second Affiliated Hospital,Chongqing Medical University

重庆医科大学生物医学工程系

⁰