Polycystic ovarian ayndrome and insulin resistance

QIU Yan; et al

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Polycystic ovarian ayndrome and insulin resistance

更新时间：2024-01-17

- Polycystic ovarian ayndrome and insulin resistance
- Journal of Chongqing Medical University Issue 3, Pages: 280-283(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院辅助生殖中心
  2. 重庆医科大学临床学院辅助生殖中心,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.7
- Published：2002，
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[1]丘彦,曾品鸿,桂文武,刘淑文,张扬,周永芳,舒为群.多囊卵巢综合征与胰岛素抵抗[J].重庆医科大学学报,2002(03):280-283.

QIU Yan, et al. Polycystic ovarian ayndrome and insulin resistance. [J]. Journal of Chongqing Medical University (3):280-283(2002)
[1]丘彦,曾品鸿,桂文武,刘淑文,张扬,周永芳,舒为群.多囊卵巢综合征与胰岛素抵抗[J].重庆医科大学学报,2002(03):280-283. DOI：

QIU Yan, et al. Polycystic ovarian ayndrome and insulin resistance. [J]. Journal of Chongqing Medical University (3):280-283(2002) DOI：

摘要

目的:了解多囊卵巢综合征（）胰岛素抵抗（）患者血清游离脂肪酸（）、肿瘤坏死因子（α）PCOSIRFFATNF-水平

以及二者与稳态模型（）的相关性。HomaModel方法:测定例患者及例非不孕患者的血清、118PCOS34PCOSFFAα的水平

根据空腹血糖及空腹胰岛素值计算指数。进一步观察有胰岛素抵抗患者用罗格列酮（文迪TNF-HomaIRPCOS雅）治疗后相关指标的变化。结果:患者血和α明显高于非者PCOSFFATNF-PCOS（P值均<;用罗格列酮治疗后患者0.05）的空腹胰岛素和肽、血糖、胰岛素和肽水平、血清、α、值均明显下降（C2h2hCFFATNF-HomaIRP值均<）。0.05结论:患者的、α水平高于正常人

二者与呈正相关

、α可作PCOSFFATNF-HomaIRFFATNF-为胰岛素抵抗治疗的观察指标。

Abstract

Objective: αTo investigate the serum FFA and TNF- levels of the PCOS with insulin resistance 、α(IR)

and the relationship between FFATNF- and the Homa IR. Methods: The serum levels of FFA and TNFα-

in 118 cases of PCOS and 34 cases of non-PCOS but infertility

were determined. According to the results of the fasting blood glucose (FBG) and the fasting insulin levels (FINS)

Homa IR was calculated. Furthermore the cases

who were PCOS with IR

were received rosiglitazone (Avandia) and observed the relevant factors changed after the treatmant. Results: α The levels of FFA and TNF- in the patients of the PCOS group were significantly higher than that in the non-PCOS group (P<0.05). In the patients who received rosiglitazone treatment

the serum αlevels of fasting insulin

fasting C peptide

2h blood glucose

2h insulin

2h C peptide

FFA

TNF-and Homa IR were decreased significantly as compared with those before the treatment (P<0.05

respectively). Conclusion: The αserum FFA and TNF- levels of the PCOS group were higher than the normals

and the two were related positively to Homa IR. FFA and αTNF- can be the criteria of the treatment for the PCOS with IR.

关键词

多囊卵巢综合征胰岛素抵抗FFATNF-αHoma IR

Keywords

PCOSinsulin resistanceFFATNF-Homa IR

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