Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit

CHEN Wenzhi; et al

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Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit

更新时间：2024-01-17

- Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit
- Journal of Chongqing Medical University Issue 3, Pages: 286-288(2002)
- 作者机构：
  
  1. 重庆医科大学医学超声工程研究所
  2. 重庆医科大学医学超声工程研究所,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332
- Published：2002，
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[1]陈文直,王智彪,白晋,伍烽,杜永洪,胡凯.VX_2兔恶性骨肿瘤模型的建立及其生物学特性观察[J].重庆医科大学学报,2002(03):286-288.

CHEN Wenzhi, et al. Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit. [J]. Journal of Chongqing Medical University (3):286-288(2002)
[1]陈文直,王智彪,白晋,伍烽,杜永洪,胡凯.VX_2兔恶性骨肿瘤模型的建立及其生物学特性观察[J].重庆医科大学学报,2002(03):286-288. DOI：

CHEN Wenzhi, et al. Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit. [J]. Journal of Chongqing Medical University (3):286-288(2002) DOI：

摘要

目的:为建立恶性骨肿瘤的大型动物模型并观察其生物学特性。方法:采用组织块移植法

将VX2肿瘤组织块移植于只兔胫骨干骺端内

通过软组织肿块大小的测定、线摄片、病理学检查和自然生存时间等指标

观察该模型的生物学51X特征。结果:肿瘤原位移植成功率

荷瘤兔自然存活时间±天

肿瘤移植后周出现肺等部位的转移。放射学特征100%35113为骨质破坏、骨膜反应和软组织肿块影。病理学检查见骨质破坏、骨膜增生

原发灶和转移灶的组织学类型一致

均为鳞癌。结论:此模型移植成功率高

生物学特征稳定

其生物学和放射学特征类似人恶性骨肿瘤

为恶性骨肿瘤的研究提供一种大型动物类型。

Abstract

Objective: To establish an experimental animal model of malignant bone tumor and observe its biological features. Methods: The VX2 tumor tissue mass was transplanted in tibia metaphysis of 51 New Zealand white rabbits. The biological features of the transplanted tumor tissue were observed by pathological and radiological examination

tumor measurement and natural survival time determination. Results: The orthotopic ±tumor growth rate was 100%. Average survival time was (3511) days. The tumor metastasized to lung and other organs in 3 weeks after transplantation. The radiological features were bone destruction

periosteal response and image of soft tissue mass. The pathological examination showed bone destruction and periosteal hyperplasia. The histological type of primary foci was coincident with that of metastatic foci. Both belonged to squamous cell carcinoma. Conclusion: The model has a very high rate of success and steady biological features. The biological and radiological features of the model are similar to those of malignant bone tumors in human

so it serves as a large animal model for the study of malignant bone tumor.

关键词

恶性骨肿瘤动物模型兔

Keywords

Malignant bone tumoranimal modelrabbit

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