Study of in vitro antibacterial activity of faropenem against 194 clinical isolates

LIU Chengwei; et al

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Study of in vitro antibacterial activity of faropenem against 194 clinical isolates

更新时间：2024-01-17

- Study of in vitro antibacterial activity of faropenem against 194 clinical isolates
- Journal of Chongqing Medical University Issue 1, Pages: 107-109(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院传染病寄生虫病研究所
  2. 重庆医科大学附属第一医院传染病寄生虫病研究所,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2006，
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[1]刘成伟,黄文祥,卓超,余登高,李崇智,郑行萍.法罗培南对临床分离194株致病菌的体外抗菌活性研究[J].重庆医科大学学报,2006(01):107-109.

LIU Chengwei, et al. Study of in vitro antibacterial activity of faropenem against 194 clinical isolates. [J]. Journal of Chongqing Medical University (1):107-109(2006)
[1]刘成伟,黄文祥,卓超,余登高,李崇智,郑行萍.法罗培南对临床分离194株致病菌的体外抗菌活性研究[J].重庆医科大学学报,2006(01):107-109. DOI：

LIU Chengwei, et al. Study of in vitro antibacterial activity of faropenem against 194 clinical isolates. [J]. Journal of Chongqing Medical University (1):107-109(2006) DOI：

摘要

目的:研究法罗培南的体外抗菌活性。方法:采用琼脂平板稀释法

测定法罗培南与头孢哌酮/舒巴坦、头孢噻肟对194株临床分离菌株的最低抑菌浓度（MIC）

并统计M IC50、MIC90及敏感率。结果:法罗培南对所有194株细菌

M IC50≤1μg/m l

MIC90≤4μg/ml

敏感率均在90%以上。对产β-内酰胺酶的大肠埃希氏菌和肺炎克雷伯氏菌

法罗培南的M IC90与头孢哌酮/舒巴坦的M IC90相近

是头孢噻肟的M IC90的1/32;对变形杆菌、卡他莫拉菌和肺炎链球菌

三者M IC90相近;对金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌

法罗培南的M IC90明显低于头孢哌酮/舒巴坦或头孢噻肟的M IC90。结论:法罗培南对临床分离致病菌具有较强的抗菌活性

对产酶株也同样具有较高的抗菌活性。法罗培南有望成为国内临床上推广使用的抗生素。

Abstract

Objective: To study in vitro antibacterial activity of faropenem.Methods: The minimum inhibitory concentration(MIC) of faropenem

cefoperazone/sulbactam or cefotaxime against 194 clinical isolates was determined by agar dilution method.MIC50

MIC90 and the susceptible rate were counted.Results: MIC50 and MIC90 of faropenem were lower than or equal to 1μg/ml and 4μg/ml for all 194 clinical isolates respectively.All susceptible rates of faropenem were more than 90%.MIC90 of faropenem was similar to that of cefoperazone/sulbactam against beta-lactamase producing Escherichia coli and klebsierlla peumoniae

but was 1/32 MIC90 of cefotaxime.MIC90 of three antibiotics was similar against Proteus spp

Moraxella catarrhalis and Streptococcus pneumoniae.MIC90 of faropenem was marked lower than that of cefoperazone/sulbactam or cefotaxime against Staphylococcus aureus

Staphylococcus epidermidis and Enterococcus faecalis.Conclusion: Antibacterial activity of faropenem against clinical isolates is very strong and it is also strongly against beta-lactamase producing bacteria.It can be expected that faropenem will be used widely in clinic in china.

关键词

法罗培南体外抗菌活性

Keywords

FaropenemIn vitro antibacterial activity

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