Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer

HE Yunfeng; et al

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Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer

更新时间：2024-01-17

- Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer
- Journal of Chongqing Medical University Issue 3, Pages: 311-313(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆医科大学检验系
  3. 重庆医科大学儿童医院
  4. 重庆市第二人民医院病理科,重庆,400016
  5. ,重庆,400060
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.14
- Published：2006，
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[1]何云锋,吴小候,罗春丽,田代印,黄蜀康.Delta N p63蛋白在膀胱癌组织中的表达及意义[J].重庆医科大学学报,2006(03):311-313+317.

HE Yunfeng, et al. Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer. [J]. Journal of Chongqing Medical University (3):311-313(2006)
[1]何云锋,吴小候,罗春丽,田代印,黄蜀康.Delta N p63蛋白在膀胱癌组织中的表达及意义[J].重庆医科大学学报,2006(03):311-313+317. DOI：

HE Yunfeng, et al. Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer. [J]. Journal of Chongqing Medical University (3):311-313(2006) DOI：

摘要

目的:探讨DeltaNp63（ΔNp63）蛋白在膀胱移行细胞癌（TCCB）中的表达及意义。方法:采用SP免疫组织化学法检测43例TCCB患者肿瘤组织、11例对照组膀胱组织ΔNp63蛋白的表达

并分析ΔNp63蛋白表达与TCCB临床分期、病理分级的关系。结果:43例TCCB组织中ΔNp63蛋白表达阳性率为100%（43/43）

对照组膀胱组织中ΔNp63蛋白表达的阳性率为18.2%（2/11）

TCCB组ΔNp63蛋白表达的阳性率明显高于正常组

差异有显著性（P<0.05）。不同临床分期肿瘤组织中ΔNp63蛋白表达的阳性率及强度

各组间ΔNp63蛋白表达的阳性率及表达强度差异无显著性（P>0.05）。不同病理分级肿瘤组织中ΔNp63蛋白表达的阳性率及强度

各组间ΔNp63蛋白表达的阳性率及表达强度差异无显著性（P>0.05）。结论:TC-CB组ΔNp63蛋白表达水平均明显高于正常组

提示ΔNp63与TCCB的发生密切相关

可能为TCCB发生的重要促进因素

ΔNp63蛋白表达水平与TCCB的临床分期、病理分级没有相关性

故ΔNp63在TCCB进展中的作用有待进一步研究。

Abstract

Objective: to explore the expression and clinical significance of delta N p63 protein in transitional cell carcinoma of the bladder(TCCB).Method: The immunohistochemical staining assay was conducted to detect expression of delta N p63 protein in 43 cases of TCCB and 11 cases of normal bladder epithelium.The relationship between delta N p63 protein expression and pathological types

clinical stages of TCCB was analyzed.Results:The expression rates of delta N p63 protein in TCCB and normal bladder epithelium were 100%(43/43)and 18.2%(2/11)respectively.The difference between the two groups was significant(P<0.05).There was no significant difference in the expression rate of delta N p63 protein in different pathological types and clinical stages of TCCB

The differences between groups were no significant.Conclusion:There is high expression of delta N p63 protein in TCCB

delta N p63 is associated with tumorigenesis in TCCB

but is not associated with pathological types and clinical stages of TCCB.Further studies will be necessary to explore the function of delta N p63 in the progression of TCCB.

关键词

膀胱癌ΔNp63

Keywords

bladder cancerDeltaN p63

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