Expression and significance of LRP and GST-πin the testis germ cell tumor

LUO Xiaoji; et al

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Expression and significance of LRP and GST-πin the testis germ cell tumor

更新时间：2024-01-17

- Expression and significance of LRP and GST-πin the testis germ cell tumor
- Journal of Chongqing Medical University Issue 3, Pages: 296-298(2006)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院外科
  2. 重庆医科大学附属儿童医院外科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.21
- Published：2006，
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[1]罗小辑,金先庆,陈瑾.LRP、GST-π在睾丸生殖细胞肿瘤中的表达及其意义[J].重庆医科大学学报,2006(03):296-298+301.

LUO Xiaoji, et al. Expression and significance of LRP and GST-πin the testis germ cell tumor. [J]. Journal of Chongqing Medical University (3):296-298(2006)
[1]罗小辑,金先庆,陈瑾.LRP、GST-π在睾丸生殖细胞肿瘤中的表达及其意义[J].重庆医科大学学报,2006(03):296-298+301. DOI：

LUO Xiaoji, et al. Expression and significance of LRP and GST-πin the testis germ cell tumor. [J]. Journal of Chongqing Medical University (3):296-298(2006) DOI：

摘要

目的:探讨睾丸生殖细胞肿瘤中LRP（Lungresistance-relatedprotein）、GST-π的表达及其临床意义。方法:应用SP免疫组织化学法检测41例术前未化疗的睾丸生殖细胞肿瘤标本LRP、GST-π的表达。结果:LRP总的表达率为41.5%

Ⅱ+Ⅲ期为LRP的表达率73.3%高于Ⅰ期23.1%（P<0.05）;LRP在精原细胞瘤中表达率为40.0%

非精原细胞生殖细胞肿瘤中的表达率为45.5%（P>0.05）。GST-π总的表达率为34.1%

Ⅰ期表达率为38.5%

Ⅱ+Ⅲ期表达率为26.7%

在精原细胞瘤中表达率为30.0%

在非精原细胞生殖细胞肿瘤中的表达率为45.5%

GST-π与睾丸生殖细胞肿瘤的临床分期及病理类型之间无显著差异（P>0.05）。结论:LRP的表达与睾丸生殖细胞肿瘤的临床分期有关

可用作判断预后有价值的指标。

Abstract

Objective: To investigate the expression of LRP

GST-πin the testicular germ cell tumor and evaluate their role in multidrug resistance of the testicular germ cell tumor.Methods: 41 samples of germ cell tumor without chemotherapy were analyzed immunohistochemically.Results: The total positive percentage of LRP in the testicular germ cell tumor was 41.5%

the frequence of LRP expression in Ⅰ stage

Ⅱ+Ⅲ stage

seminoma and non-seminoma germ cell tumor was 23.1%

73.3%

40.0% and 45.5% respectively.There was significant difference of the LRP expression between I stage and Ⅱ+Ⅲ stage in the testis germ cell tumor(P<0.05).The total positive percentage of the expression of GST-π was 34.1%;the frequence of LRP expression in I stage

Ⅱ+Ⅲstage

seminoma and non-seminoma germ cell tumor was 38.5%

26.7%

30.0%and 45.5% respectively.The expression of GST-πwas not associated with clinical stage and pathological types(P>0.05).Conclusion: The expression of LRP was correlational with the clinical stage of the testicular germ cell tumor

and LRP expression may be an important prediction of patients with testicular germ cell tumor.【

关键词

睾丸生殖细胞肿瘤LRPGST-π

Keywords

The testicular germ cell tumorLRPGST-π

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LUO Xiaoji

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陈瑾

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Department of Surgery,the Children’s Hospital,Chongqing Medical University

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