Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells

HE Song; et al

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Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells

更新时间：2024-01-17

- Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells
- Journal of Chongqing Medical University Issue 5, Pages: 677-680(2006)
- 作者机构：
  
  1. 重庆医科大学附属第二医院消化内科
  2. 基础医学院病理生理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.7
- Published：2006，
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[1]何松,左国庆,张燕,汤为学.顺铂、氧化苦参碱对肝癌QGY细胞生长及端粒酶活性的影响[J].重庆医科大学学报,2006(05):677-680.

HE Song, et al. Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells. [J]. Journal of Chongqing Medical University (5):677-680(2006)
[1]何松,左国庆,张燕,汤为学.顺铂、氧化苦参碱对肝癌QGY细胞生长及端粒酶活性的影响[J].重庆医科大学学报,2006(05):677-680. DOI：

HE Song, et al. Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells. [J]. Journal of Chongqing Medical University (5):677-680(2006) DOI：

摘要

目的:观察顺铂、氧化苦参碱对人肝癌细胞株QGY端粒酶活性的影响

进一步探讨两种药物的可能作用机制。方法:采用人肝癌细胞株QGY作为研究对象

MTT法检测不同浓度和作用时间的药物对细胞增殖的抑制作用

以及对QGY细胞粘附能力的影响;流式细胞仪分析细胞周期的分布及凋亡;PCR-ELISA法检测端粒酶活性的变化。结果:两种药物均具有抗QGY细胞增殖、阻滞细胞周期、诱导凋亡及抑制端粒酶活性的作用。结论:对端粒酶活性的抑制可能是两种药物发挥抗肿瘤作用的机制之一。

Abstract

Objective:To investigate the anti-cancer mechanism of cisplatin

oxymatrine by observing their effects on telomerase activity.Methods:The inhibition of proliferation in QGY cells were estimated by MTT-test.Distribution of cell cycle and apoptosis were analysed using flow cytometry.The changes of telomerase activity were detected by PCR-ELISA method.Results:These two drugs could inhibit the proliferation of QGY cells

block the cell cycle

induce its apoptosis and inhibit the activity of telomerase.Conclusion:The inhibition of telomerase activity may be one of the mechanisms for the anti-cancer effect of the two drugs.

关键词

肝细胞癌端粒酶顺铂氧化苦参碱

Keywords

hepatocellular carcinomatelomerasecisplatinoxymatrine

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