Expression and Significance of Fas and FasL in Hyperthyroid Cardiopathy

LI Huakang; et al

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Expression and Significance of Fas and FasL in Hyperthyroid Cardiopathy

更新时间：2024-01-17

- Expression and Significance of Fas and FasL in Hyperthyroid Cardiopathy
- Journal of Chongqing Medical University Issue 5, Pages: 673-676(2006)
- 作者机构：
  
  1. 重庆医科大学附属第二医院心内科
  2. 重庆医科大学附属第二医院心内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.8
- Published：2006，
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[1]李华康,戴引,殷跃辉.Fas、FasL在兔甲亢性心脏病中的表达及其意义[J].重庆医科大学学报,2006(05):673-676.

LI Huakang, et al. Expression and Significance of Fas and FasL in Hyperthyroid Cardiopathy. [J]. Journal of Chongqing Medical University (5):673-676(2006)
[1]李华康,戴引,殷跃辉.Fas、FasL在兔甲亢性心脏病中的表达及其意义[J].重庆医科大学学报,2006(05):673-676. DOI：

LI Huakang, et al. Expression and Significance of Fas and FasL in Hyperthyroid Cardiopathy. [J]. Journal of Chongqing Medical University (5):673-676(2006) DOI：

摘要

目的:研究Fas、FasL在甲亢性心脏病心肌组织中的表达

并探讨其在甲亢性心脏病发病中的可能作用及临床意义。方法:新西兰白兔20只

随机分为两组:实验组和对照组

每组各10只。实验组腹腔注射左旋甲状腺素（50μg/kg/d×28天）建立甲亢动物模型。分别于实验第0、7、14、21、28天测定兔心率、体重、体温

耳缘静脉采血

用放免法测TT3、TT4。实验前后超声心动图检测左室（LV）、左室后壁（LVPW）、室间隔（IVS）厚度、左房（LA）内径及左室射血分数（LVEF）。光镜下观察心房、心室肌形态结构

测定心肌细胞直径

Masson染色测定胶原容积分数（CVF）

免疫组化半定量检测Fas、FasL在左、右心房及心室的表达。结果:实验组LA、LV、LVPW、IVS厚度

心室质量指数

心肌细胞直径、CVF以及左房、左室Fas阳性表达较对照组明显增加

两者比较有统计学意义（P<0.05）。结论:左旋甲状腺素（Levothyroxine L-Thy）可诱导心肌肥厚、心肌细胞结构改变、心肌细胞凋亡以及心肌间质纤维化;Fas/FasL系统可能与甲亢性心脏病的发生发展有关。

Abstract

Objective:To study the expression of Fas and FasL in hyperthyroid cardiopathy and to explore its possible effect and clinical significance in the pathogenesis of the hyperthyroid cardiopathy.Methods:Twenty New Zealand rabbits were randomly divided into two groups: control group(n =10) and experimental group(n =10).Hyperthyroidism animal model was established by peritoneal injection of Levothyroxine(L-Thy) in experimental group.All the rabbits were followed up for 4 weeks.Every 7 days blood samples were obtained.Serum TT3 and TT4 were measured with radioimmunoassays(RIAs).Electrocardiogram(ECG) was performed to determine heart rate(HR).All the rabbits underwent echocardiography and the thickness of IVS?LV?LA?LVPW and LVEF were measured at the end of the follow-up period.Ventricular tissues were collected at 4th weeks.Cardiac hypertrophy index

cardiomyocyte diameter

structural change were detected.Cardiac fibrosis was displayed by Masson stain and collagen volume fraction(CVF)was measured using pathological image analytic system.Protein of Fas and FasL were localized by immunohistochemistry and semi-quantified with pathological image analytic system.Results: In experimental group

the thickness of IVS?LV?LA?LVPW

cardiac quality index

cardiomyocyte diameter

collagen volume fraction(CVF) and the expression of Fas in left atrium and left ventricle increased obviously(P<0.05).Conclusion:L-Thy could induce myocardial hypertrophy

structural change of cadiomyocyte

myocardium interstitial fibrosis and cell apoptosis.The system of Fas/FasL may correlate with the pathogenesis and course of the hyperthyroid cardiopathy.

关键词

甲亢性心脏病FasFasL

Keywords

Hyperthyroid cardiopathyFasFasL

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重庆医科大学第二临床学院内科

Department of Internal Medicine, the Second College of Clinical Medicine, Chongqing Medical University

重庆医科大学临床学院妇产科,重庆医科大学临床学院妇产科,四川省妇幼保健院,重庆市第四人民医院,重庆医科大学第二临床学院重庆　400016,重庆　400016

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