Objective: To observe the clinical effect of massage combined with Hyperbaric Oxygen(HBO) on improving the intelligence of infants with moderate or severe Hypoxic Ischemic Encephalophy(HIE).Methods: 122 newborns aged less than 2 days were randomly divided into four groups.33 cases in the control group were treated with cerebrolysin

29 cases in the second group were treated with cerebrolysin and massage

32 cases in the third group were treated with cerebrolysin and HBO

and 28 cases in the fourth group with cerebrolysin

HBO and massage.The mental development index(MDI) and the psychomotor developmental index(PDI) were observed when they were 3?6?9?12 and 18 months old.Results: The MDI and PDI of infants with moderate HIE was significantly higher in the fourth group than those in the control group(P<0.01)

which were also significantly higher in the second and third groups than those in the control group(P<0.05)

and grew higher with time

till reached to normal level after 18 months’ treatment.The fourth group showed the optional efficiency.The MDI and PDI grew higher with time in the control group

and can be in dull normal or borderline.The MDI and PDI of infants with severe HIE were not remarkably higher in the second and third group(P>0.05)

and no higher in the control group as well.The MDI and PDI were in mental retardation after 18 months’ treatment

mostly accompanied by cerebral palsy which were higher in the fourth group than those in the control group

and grew higher with time

and can be in borderline after 18 months’ treatment.There was statistically significant difference between them(P<0.05).Conclusion: HBO conbined with massage can improve the mental development of infants with moderate or severe HIE.