Expression and significance of heme oxyenase-1 in benign and malignant breast tissue

LIU Shengchun; et al.

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Expression and significance of heme oxyenase-1 in benign and malignant breast tissue

更新时间：2024-01-17

- Expression and significance of heme oxyenase-1 in benign and malignant breast tissue
- Journal of Chongqing Medical University Issue 4, Pages: 561-565(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院普外科重庆市普外科重点实验室
  2. 重庆医科大学附属第一医院普外科重庆市普外科重点实验室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9;R655.8
- Published：2006，
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[1]刘胜春,吴凯南.HO-1在良、恶性乳腺组织中的表达及意义[J].重庆医科大学学报,2006(04):561-565.

LIU Shengchun, et al.. Expression and significance of heme oxyenase-1 in benign and malignant breast tissue. [J]. Journal of Chongqing Medical University (4):561-565(2006)
[1]刘胜春,吴凯南.HO-1在良、恶性乳腺组织中的表达及意义[J].重庆医科大学学报,2006(04):561-565. DOI：

LIU Shengchun, et al.. Expression and significance of heme oxyenase-1 in benign and malignant breast tissue. [J]. Journal of Chongqing Medical University (4):561-565(2006) DOI：

摘要

目的:探讨血红素氧合酶-1（HO-1）在乳腺良恶性组织中的表达及意义。方法:分别用RT-PCR4免疫组化、Western blot蛋白印迹杂交检测正常乳腺组织10例;乳腺增生症18例;乳腺纤维腺瘤20例;乳腺癌25例组织中的HO-1mRNA及HO-1蛋白

并检测HO-1酶活性

探讨HO-1在乳腺肿瘤组织中表达及意义。结果:乳腺癌组织中的HO-1mRNA表达（0.3755±0.0628）明显高于正常乳腺（0.1199±0.0810）、乳腺增生（0.15021±0.0479）及乳腺纤维腺瘤组（0.1834±0.054）（t=2.2992

P<0.01）

乳腺良、恶性肿瘤组织中的HO-1表达（23.4617±7.0136

34.2712±4.3423）均高于正常乳腺（4.2742±0.821）及乳腺增生组（6.2525±1.0032）（P<0.05）。乳腺良、恶性肿瘤组织中的HO-1酶活性（1.1458±0.0458

1.4646±0.04892）均高于正常乳腺（0.8935±0.0271）及乳腺增生组（0.9375±0.0302）（P<0.01）

乳腺癌组织中的HO-1酶活性高于纤维腺瘤（t=3.7546

P<0.01）。结论:HO-1mRNA、蛋白表达以及HO-1酶活性的变化与乳腺良性病变及癌变存在相关性

提示HO-1对肿瘤细胞存在保护作用。

Abstract

Objective: To investigate the expression and significance of heme oxyenase-1(HO-1) in benign and malignant breast tissue.Methods: HO-1 mRNA

HO-1 protein and enzyme activity of HO-1 in 10 cases of normal breast tissue

18 of hyperplasia

20 of adenoma and 25 of carcinoma were evaluated by RT-PCR

immunohistochemistry and Western blot respectively

and the significance of HO-1 in breast tissue was discussed.Results: The expression of HO-1 mRNA in breast carcinoma tissue(0.3755±0.0628) was higher than those in normal breast tissue(0.1199±0.0810)

breast hyperplasia(0.1502±0.0479) and breast adenoma(0.1834±0.0541)(t=2.2992

P<0.01)

HO-1 protein expression in benign and malignant breast tumor tissue(23.4617±7.0136

34.2712±4.3423) were higher than those in normal(4.2742±0.8216) and hyperplasia breast tissue(6.2525±1.0032)(P<0.05)

and at the same time

HO-1 enzyme activity in benign and malignant breast tumor tissue(1.1458±0.0458

1.4646±0.0489)were higher than those in normal(0.8935±0.0271) and hyperplasia(0.9375±0.0302)(P<0.01) too and that of carcinoma tissue was higher than that in breast adenoma(t= 3.7546

P<0.01)?Conclusions:HO-1mRNA?protein expression and HO-1 enzyme activity were associated with benign and malignant breast tissue

which indicates that HO-1 can protect carcinoma cell in breast.

关键词

乳腺增生乳腺肿瘤血红素氧合酶-1

Keywords

Breast hyperplasiabreast carcinomaHeme oxygenase-1

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