Objective: To investigate the expression of Skp2

c-Myc and P27kip1 protein

their association with clinicopathological features and the correlation between one and another.Method:Skp2

c-Myc and P27kip1 protein were examined by using immunochistochemical staining method in 20 cases of normal colorectal mucosa

20 cases of colorectal adenomatous polyp and 60 cases of colorectal cancer

and analysed the relationship with clinicopathologic features and between Skp2 with c-Myc and P27kip1 protein.Results:The positive rates of Skp2

c-Myc and P27kip1 protein in colorectal cancer were 71.67%

66.67% and 21.67% respectively.Moreover

the expression levels of Skp2 and P27kip1 protein in colorectal cancer were significantly associated with the pathologic grade

invasion deep

clinical stage and lymph node metastasis

c-Myc associated with the invasion deep

clinical stage and lymph node metastasis

but were independent of age and sex.Besides

in colorectal cancer

the expression levels of Skp2 and P27kip1 protein were inversely correlated

and the expression levels of Skp2 and c-Myc protein were positively correlated.Conclusions:The expression of Skp2

c-Myc and P27kip1 protein are associated with occurrence and development in colorectal cancer through their alteration

which is very important for assessment of malignancy degree and prognosis in colorectal cancer

and detection cancer of their expression provides theoretical basis for targetting therapy of colorectal.