Expression and significance of E2F3 in bladder urothelial carcinoma

YANG Yang; et al

您当前的位置：

首页 >

文章列表页 >

Expression and significance of E2F3 in bladder urothelial carcinoma

更新时间：2024-01-17

- Expression and significance of E2F3 in bladder urothelial carcinoma
- Journal of Chongqing Medical University Issue 1, Pages: 37-39(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆医科大学附属第一医院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.14
- Published：2007，
扫描看全文
[1]杨洋,唐伟.E2F3在膀胱移行细胞癌中的表达及意义[J].重庆医科大学学报,2007(01):37-39.

YANG Yang, et al. Expression and significance of E2F3 in bladder urothelial carcinoma. [J]. Journal of Chongqing Medical University (1):37-39(2007)
[1]杨洋,唐伟.E2F3在膀胱移行细胞癌中的表达及意义[J].重庆医科大学学报,2007(01):37-39. DOI：

YANG Yang, et al. Expression and significance of E2F3 in bladder urothelial carcinoma. [J]. Journal of Chongqing Medical University (1):37-39(2007) DOI：

摘要

目的:通过检测E2F3mRNA在膀胱移行细胞癌组织及正常膀胱移行上皮组织中的表达

探讨其与膀胱移行细胞癌发生发展的关系。方法:通过RT-PCR方法检测34例膀胱移行细胞癌组织及19例正常膀胱移行上皮组织中E2F3mRNA的表达情况。结果:E2F3mRNA在膀胱移行细胞癌及正常膀胱移行上皮组织中的阳性表达率分别为47.1%（16/34）和0%（0/19）。膀胱移行细胞癌组织中E2F3mRNA的表达率明显高于正常膀胱移行上皮组织（P<0.005）。其中膀胱移行细胞癌组织中E2F3mR-NA的表达率随肿瘤分级、分期增高而相应增高（P<0.05）。结论:E2F3基因可能通过参与细胞周期调控

在膀胱移行细胞癌的发生发展中起到促进作用。

Abstract

Objective:To investigate the expression of E2F3 mRNA in bladder urothelial carcinoma and normal bladder urothelial tussue to explore its relationship with the genesis and progression of bladder urothelial carcinoma.Methods:The expression of E2F3 mRNA in 34 cases of bladder urothelial carcinoma and 19 cases of normal bladder urothelial tussue was examined by RT-PCR.Result:The positivity rates of E2F3 mRNA in bladder urothelial carcinomas and normal bladder urothelial tussues were 47.1%(16/34) and 0%(0/19) respectively.The expression level of E2F3 mRNA in bladder urothelial carcinomas was significantly higher than that in normal bladder urothelial tussues(P <0.005).The expression rate of E2F3 mRNA in bladder urothelial carcinoma was positively correlated with tumor grade and clinical stage(P <0.05).Conclusion:E2F3 might play a promoting role in the genesis and progression of bladder urothelial carcinoma by controlling cell cycle.

关键词

膀胱移行细胞癌E2F3RT-PCR

Keywords

Bladder urothelial carcinomaE2F3RT-PCR

references

Views

111

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of leukaemia inhibitory factor from endometria of estrus cycle in mouse

Expression of connexin43 protein and mRNA in patients with endometriosis and its significance

The clone of human LIF gene and construction of its eukaryotic expression vector

Expression of neural stem cell-specific molecules cultured in vitro and induced mononuclear cells derived from human cord blood

Construction and expression of eukaryotic expression vector for hepatitis B virus X gene containing EGFP

Related Author

刘孝云

魏莎莉

et al

YANG Rong

令狐华

et al

QIAO Jian

王建伟

Related Institution

重庆医科大学计划生育医学系

Department of Family Planning ， Chongqing Medical University

重庆医科大学临床学院妇产科

Department of Obstetrics and Gynecology,College of Clinical Medicine,Chongqing Medical University

重庆市生物化学与分子药理学重点实验室

⁰